ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2021
Depressive symptoms and cognitive impairment: A 10-year follow-up study from the Survey of Health, Ageing and Retirement in Europe.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 47 citations in OpenAlex.
- Interventions to Improve Depressive Symptoms in Community-Dwelling Older Adults: A Scoping Review.Journal of prevention (2022) · 2026Article
- Tracking the Continuous Time Dynamics of Tau and Depressive Symptoms across the Alzheimer's Disease Continuum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Depression and cognition: is there a bidirectional relationship?Aging & mental health · 2026Article
- Physical frailty, depressive symptoms, and cognitive decline before and after Parkinson's disease diagnosis: a population-based prospective study of the SHARE and ELSA cohorts.NPJ Parkinson's disease · 2026Article
- Is all movement equal at every age? Differentiating the impact of physical activity types on depressive symptoms and mental acuity in an aging India.Archives of public health = Archives belges de sante publique · 2026Article
- Older caregivers and care recipients in Europe: a cluster analysis according to health and social outcomes.Archives of public health = Archives belges de sante publique · 2026Article
- Socio-emotional well-being is associated with cognitive function and informant-rated cognitive decline: Results from the Harmonized Cognitive Assessment Protocol in Europe.Journal of the International Neuropsychological Society : JINS · 2026Article
- Cognitive impairment among widowed older adults in India: a decomposition analysis of gender gap.BMC psychology · 2026Article
- Associations between depressive symptoms and cognitive function in China older adults based on a dual-trajectory model.BMC public health · 2026Article
- Plasma phosphorylated tau 217 and neurofilament light chain on the association between depressive symptoms and cognitive decline: The Shanghai Aging Study.Psychological medicine · 2026Article
- Multidimensional Depressive Symptom Exposure and Incident Cognitive Decline: A Prospective Cohort Study.Depression and anxiety · 2026Article
- Hearing loss and cognitive function among older adults in 18 high-income countries: Moderating and Mediating factors.Research square · 2025Article
- Cumulative handgrip strength and trajectories of depressive symptoms in older adults: evidence from two cohort studies.BMC public health · 2025Article
- Defining the contributions of tau pathology in the amygdala to increasing depressive symptoms in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cognitive Frailty and Health Care Utilization and Costs Among Middle-Aged and Older Adults: Findings from Four Longitudinal Cohort Studies.Aging and disease · 2025Article
- Measurement invariance of a general cognitive performance measure across 27 European countries and Israel.European journal of ageing · 2025Article
- Depressive intensity, duration, and their associations with cognitive decline: a population-based study in Korea.GeroScience · 2025Article
- Self- and Informant-Report Cognitive Decline Discordance and Mild Cognitive Impairment Diagnosis.JAMA network open · 2025Observational
- Association of Cognitive Frailty With Subsequent All-Cause Mortality Among Middle-Aged and Older Adults in 17 Countries.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Article
- The influencing factors of cognitive impairment in elderly individuals in Chengdu city: a cross-sectional study based on AD8.BMC geriatrics · 2025Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDepressive symptoms and cognitive impairment often coexisted in the elderly. This study investigates the effect of late-life depressive symptoms on risk of mild cognitive impairment (MCI).
methodsA total of 14,231 dementia- and MCI free participants aged 60+ from the Survey of Health, Ageing, and Retirement in Europe were followed-up for 10 years to detect incident MCI. MCI was defined as 1.5 standard deviation (SD) below the mean of the standardized global cognition score. Depressive symptoms were assessed by a 12-item Europe-depression scale (EURO-D). Severity of depressive symptoms was grouped as: no/minimal (score 0-3), moderate (score 4-5), and severe (score 6-12). Significant depressive symptoms (SDSs) were defined as EURO-D score ≥ 4.
resultsDuring an average of 8.2 (SD = 2.4)-year follow-up, 1,352 (9.50%) incident MCI cases were identified. SDSs were related to higher MCI risk (hazard ratio [HR] = 1.26, 95% confidence intervals [CI]: 1.10-1.44) in total population, individuals aged 70+ (HR = 1.35, 95% CI: 1.14-1.61) and women (HR = 1.28, 95% CI: 1.08-1.51) in Cox proportional hazard model adjusting for confounders. In addition, there was a dose-response association between the severity of depressive symptoms and MCI incidence in total population, people aged ≥70 years and women (p-trend <0.001).
conclusionsSignificant depressive symptoms were associated with higher incidence of MCI in a dose-response fashion, especially among people aged 70+ years and women. Treating depressive symptoms targeting older population and women may be effective in preventing MCI.
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