ArticleClinical epigenetics2021
Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation.
Article in Clinical epigenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Multi-Omics Identification of Key Immune Molecules in Gestational Diabetes Mellitus: FKBP5 and HLA-DQA1 as Candidate Biomarkers.International journal of general medicine · 2026Article
- The mechanism and clinical significance of FKBP5 gene DNA methylation in various psychiatric, metabolic and tumor-related diseases.Frontiers in genetics · 2026Review
- Dynamic change of novel systemic inflammation markers in predicting perinatal outcomes after antenatal corticosteroids in preeclampsia.Medicine · 2025Observational
- Sex-specific effects of betamethasone on glucocorticoid and apoptotic signalling pathways in the sheep placenta.The Journal of physiology · 2025Article
- Neonatal outcome in late preterm twin gestation: impact of antenatal corticosteroids therapy before 34 weeks.BMC pregnancy and childbirth · 2025Article
- Perinatal hypoxia-mediated neurodevelopment abnormalities in congenital heart disease mouse model.Molecular medicine (Cambridge, Mass.) · 2025Article
- Delving Into the Interaction Between Exercise and Diabetes on Methylation of the FKBP5 Gene.Journal of diabetes research · 2025Article
- Prenatal exposures and cell type proportions are main drivers ofNeurobiology of stress · 2024Article
- Sex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis.Cellular and molecular life sciences : CMLS · 2024Article
- Mitochondrial ROS Accumulation Contributes to Maternal Hypertension and Impaired Remodeling of Spiral Artery but Not IUGR in a Rat PE Model Caused by Maternal Glucocorticoid Exposure.Antioxidants (Basel, Switzerland) · 2023Article
- Understanding the role of placental pathophysiology in the development of bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2022Review
- Evaluation of cross-platform compatibility of a DNA methylation-based glucocorticoid response biomarker.Clinical epigenetics · 2022Article
- Low reliability of DNA methylation across Illumina Infinium platforms in cord blood: implications for replication studies and meta-analyses of prenatal exposures.Clinical epigenetics · 2022Article
- Reliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies.Cellular and molecular life sciences : CMLS · 2022Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 6 countries.
Funding
Abstract
backgroundGlucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of preterm labor is common practice. Adverse short- and long-term effects of antenatal sGCs have been reported, but their effects on placental epigenetic characteristics have never been systematically studied in humans.
resultsWe tested the association between exposure to the sGC betamethasone (BET) and placental DNA methylation (DNAm) in 52 exposed cases and 84 gestational-age-matched controls. We fine-mapped associated loci using targeted bisulfite sequencing. The association of placental DNAm with gene expression and co-expression analysis on implicated genes was performed in an independent cohort including 494 placentas. Exposure to BET was significantly associated with lower placenta DNAm at an enhancer of FKBP5. FKBP5 (FK506-binding protein 51) is a co-chaperone that modulates glucocorticoid receptor activity. Lower DNAm at this enhancer site was associated with higher expression of FKBP5 and a co-expressed gene module. This module is enriched for genes associated with preeclampsia and involved in inflammation and immune response.
conclusionsOur findings suggest that BET exposure during pregnancy associates with few but lasting changes in placental DNAm and may promote a gene expression profile associated with placental dysfunction and increased inflammation. This may represent a pathway mediating GC-associated negative long-term consequences and health outcomes in offspring.
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