ArticleBMC infectious diseases2021
Characterizing social-ecological context and success factors of antimicrobial resistance interventions across the One Health spectrum: analysis of 42 interventions targeting E. coli.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Disrupting antimicrobial resistance in food systems from a One Health perspective: a complex systems analysis in Canada, Senegal and the Netherlands.BMC global and public health · 2026Article
- The emergence of highly resistant and hypervirulentEmerging microbes & infections · 2025Article
- CTX-M-ProducingInfection and drug resistance · 2025Review
- Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use.Nature communications · 2024Article
- Review
- Social and ecological determinants of antimicrobial resistance in Africa: a systematic review of epidemiological evidence.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Review
- Exploring the factors that contribute to the successful implementation of antimicrobial resistance interventions: a comparison of high-income and low-middle-income countries.Frontiers in public health · 2023Article
- Emergence and Dissemination of Extraintestinal Pathogenic High-Risk International Clones ofLife (Basel, Switzerland) · 2022Review
- Escherichia coli ST1193: Following in the Footsteps of E. coli ST131.Antimicrobial agents and chemotherapy · 2022Review
- Genomic Epidemiology of Global Carbapenemase-Producing Escherichia coli, 2015-2017.Emerging infectious diseases · 2022Article
- Challenges and Lessons Learned in the Development of a Participatory Learning and Action Intervention to Tackle Antibiotic Resistance: Experiences From Northern Vietnam.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundAntimicrobial resistance (AMR) is among the most pressing One Health issues. While interventions and policies with various targets and goals have been implemented, evidence about factors underpinning success and failure of interventions in different sectors is lacking. The objective of this study is to identify characteristics of AMR interventions that increase their capacity to impact AMR. This study focuses on AMR interventions targeting E. coli.
methodsWe used the AMR-Intervene framework to extract descriptions of the social and ecological systems of interventions to determine factors contributing to their success.
resultsWe identified 52 scientific publications referring to 42 unique E. coli AMR interventions. We mainly identified interventions implemented in high-income countries (36/42), at the national level (16/42), targeting primarily one sector of society (37/42) that was mainly the human sector (25/42). Interventions were primarily funded by governments (38/42). Most intervention targeted a low leverage point in the AMR system, (36/42), and aimed to change the epidemiology of AMR (14/42). Among all included publications, 55% (29/52) described at least one success factor or obstacle (29/52) and 19% (10/52) identified at least one success factor and one obstacle. Most reported success factors related to communication between the actors and stakeholders and the role of media, and stressed the importance of collaboration between disciplines and external partners. Described obstacles covered data quality, access to data and statistical analyses, and the validity of the results.
conclusionsOverall, we identified a lack of diversity regarding interventions. In addition, most published E. coli interventions were poorly described with limited evidence of the factors that contributed to the intervention success or failure. Design and reporting guidelines would help to improve reporting quality and provide a valuable tool for improving the science of AMR interventions.
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