Evidence map›Paper›PMID 34445956›Full record

ArticleBMC infectious diseases2021

Immunologic biomarkers, morbidity and mortality among HIV patients hospitalised in a Tertiary Care Hospital in the Brazilian Amazon.

Wellington Mota Gama, Carlos Henrique Michiles Frank, Taynná Vernalha Rocha Almeida, Daniel Silva Dos Santos, Yury Oliveira Chaves, Danielle Furtado da Silva, Patrícia Puccinelli Orlandi, Flávio Ribeiro Pereira, Gleicienne Feliz Magalhães, Bárbara Jóse Baptista and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Observational
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Wellington Mota GamaPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Manaus, Brazil.
Carlos Henrique Michiles FrankFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Taynná Vernalha Rocha AlmeidaFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil. taynnavra@gmail.com.ORCID http://orcid.org/0000-0001-9872-2420
Daniel Silva Dos SantosPrograma de Pós-Graduação em Biologia da Relação Patógeno Hospedeiro, Instituto Leônidas e Maria Deane, Manaus, Brazil.
Yury Oliveira ChavesPrograma de Pós-Graduação em Biologia da Relação Patógeno Hospedeiro, Instituto Leônidas e Maria Deane, Manaus, Brazil.
Danielle Furtado da SilvaPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Manaus, Brazil.
Patrícia Puccinelli OrlandiPrograma de Pós-Graduação em Biologia da Relação Patógeno Hospedeiro, Instituto Leônidas e Maria Deane, Manaus, Brazil.
Flávio Ribeiro PereiraFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Gleicienne Feliz MagalhãesPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Manaus, Brazil.
Bárbara Jóse BaptistaFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Viviane Lago de Oliveira SilvaPrograma de Pós-Graduação em Ciências da Saúde, Universidade Federal do Amazonas, Manaus, Brazil.
Antônio Alcirley da Silva BalieiroPrograma de Pós-Graduação em Biologia da Relação Patógeno Hospedeiro, Instituto Leônidas e Maria Deane, Manaus, Brazil.
Monique Freire SantanaPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil.
Roberta Lins GonçalvesPrograma de Pós-Graduação em Ciências da Saúde, Universidade Federal do Amazonas, Manaus, Brazil.
Allyson Guimarães da CostaPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Manaus, Brazil.
Marcelo Cordeiro Dos SantosInstituto Aggeu Magalhaes, Fundação Oswaldo Cruz-Fiocruz, Recife, Brazil.
Luís Carlos de Lima FerreiraFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Marcus Vinicius Guimaraes LacerdaFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Paulo Afonso NogueiraPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Manaus, Brazil. paulo.nogueira@fiocruz.br.
Fundação de Medicina Tropical · BRUniversidade Federal do Amazonas · BRFundação Oswaldo Cruz · BRUniversidade do Estado do Amazonas · BR

Funding

CAPES/PROCAD 88887.321243/2019-00INOVA - FIOCRUZ VPPCB-007-FIO-18
6 · The paper itself

Abstract

backgroundThe irregular use of antiretroviral therapy (ART) and late diagnosis still account for a large part of HIV-associated mortality in people living with HIV (PLHIV). Herein, we describe HIV-associated morbidity among hospitalised HIV/AIDS patients with advanced immunosuppression and assess the comorbidities, laboratory parameters, and immunological markers associated with mortality.

methodsThe cross-sectional study was conducted at the Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD) in Manaus, Brazil. In all, 83 participants aged between 12 and 70 years were enrolled by convenience within 72 h of their hospitalisation. Clinical and laboratory data were obtained from electronic medical records. We prospectively measured the cytokines Th1/Th2/Th17 and inflammatory cytokines IL-8, IL-1β, and IL-12 using cytometric bead array, and the soluble CD14 using in-house enzyme-linked immunosorbent assay.

resultsThe HIV/AIDS inpatients presented a scenario of respiratory syndromes as the most prevalent comorbidity. Almost all patients had CD4 T counts below 350 cells/mL and the mortality rate was 20.5%. Pulmonary tuberculosis, neurotoxoplasmosis and oropharyngeal-esophageal candidiasis were the most prevalent opportunistic infections. TB and weight loss were more prevalent in HIV/AIDS inpatients who died. The Mann Whitney analysis showed that those who died had higher platelet distribution width (PDW) on admission, which is suggestive for platelet activation. The Poisson multivariate analysis showed the prevalence of TB, digestive syndrome and increases in IL-8 and lactate dehydrogenase (LDH) associated to death.

conclusionsThe advanced immunosuppression characterized by the opportunistic infections presented in these HIV/AIDS inpatients was the major factor of mortality. The role of platelet activation in worse outcomes of hospitalisation and the IL-8 associated with the context of advanced immunosuppression may be promising markers in the prediction of mortality in HIV/AIDS patients.

Indexed as

HIV InfectionsAdolescentAdultAgedBiomarkersBrazilCD4 Lymphocyte CountChildCross-Sectional StudiesHumansMiddle AgedMorbidityTertiary Care CentersYoung AdultBiomarkersAcquired immunodeficiency syndromeAIDS-related opportunistic infectionsBiomarkers(MeSH):HIVMorbidityMortality

Identifiers

PMID34445956
PMCPMC8394190
OpenAlexW3113447933

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.