ArticleBMC microbiology2021
Emerging MDR-Mycobacterium avium subsp. avium in house-reared domestic birds as the first report in Egypt.
Article in BMC microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed.
- Current perspectives on avian tuberculosis in domestic and wild birds: Molecular diagnostics, genomic surveillance, and vaccination challenges.Open veterinary journal · 2026Review
- Comparative Study of Clinical Examinations, Necropsy Findings, and X-Ray Signs in Naturally Infected Pigeons to Avian Tuberculosis.Archives of Razi Institute · 2025Article
- A Comprehensive Review of Antibiotics and Antimicrobial Resistance in the Aquaculture Sector of the World and Bangladesh.International journal of microbiology · 2025Review
- Antimicrobial Peptides: The Game-Changer in the Epic Battle Against Multidrug-Resistant Bacteria.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Quorum Sensing Inhibitors: An Alternative Strategy to Win the Battle against Multidrug-Resistant (MDR) Bacteria.Molecules (Basel, Switzerland) · 2024Review
- Isolation of Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Gallibacterium anatis infection in poultry: a comprehensive review.Tropical animal health and production · 2023Review
- Phage Therapy, a Salvage Treatment for Multidrug-Resistant Bacteria Causing Infective Endocarditis.Biomedicines · 2023Review
- Pathognomonic features of Pasteurella multocida isolates among various avian species in Sharkia Governorate, Egypt.World journal of microbiology & biotechnology · 2023Article
- Nanotechnology as a Promising Approach to Combat Multidrug Resistant Bacteria: A Comprehensive Review and Future Perspectives.Biomedicines · 2023Review
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- High Levels of Multidrug-Resistant and Beta-Lactamase-Producing Bacteria in Meat and Meat Contact Surfaces, Debre Berhan Town, Ethiopia.Infection and drug resistance · 2023Article
- Identification and Phylogenetic Analysis ofTransboundary and emerging diseases · 2023Article
- Epidemiological and Antimicrobial Resistant Patterns, and Molecular Mechanisms of Carbapenem-ResistantInfection and drug resistance · 2023Article
- Antimicrobial Resistance Patterns, Sequence Types, Virulence and Carbapenemase Genes of Carbapenem-ResistantInfection and drug resistance · 2023Article
- Antibacterial efficacy of silver nanoparticles (AgNPs) against metallo-β-lactamase and extended spectrum β-lactamase producing clinically procured isolates of Pseudomonas aeruginosa.Scientific reports · 2022Article
- A First Report of Molecular Typing, Virulence Traits, and Phenotypic and Genotypic Resistance Patterns of Newly Emerging XDR and MDRPathogens (Basel, Switzerland) · 2022Article
- Evolutionary conservation of motifs withinVeterinary world · 2022Article
- A strategy design based on antibiotic‑resistance and plasmid replicons genes of clinical Escherichia coli strains.Bioengineered · 2022Article
- Article
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10 authors.
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Abstract
backgroundAvian tuberculosis is a chronic and zoonotic disease that affects a wide variety of birds, mammals, and humans. This study aimed to estimate the frequency of Mycobacterium avium subsp. avium in some domestic birds based on molecular diagnosis, antibiogram profile, and PCR-based detection of inhA, rpoB, rpsL, and otrB antibiotic resistance-related genes.
methodsA total of 120 fecal samples were collected from small flocks of house-reared domestic birds at Ismailia Governorate, Egypt. The collected samples were processed and subjected to the bacteriological examination. The antimicrobial susceptibility testing of the recovered isolates was performed using the broth microdilution method for the detection of minimum inhibitory concentrations (MICs). The genetic detection of the IS901confirmatory gene, inhA, rpoB, rpsL, and otrB genes was carried out using PCR.
resultsThe frequency of M. avium subsp. avium was 4.1% (5/120); 10% (4/40) in ducks, and 2.5% (1/10) in geese. The identification of the recovered isolates was confirmed using PCR, where all the tested isolates were positive for IS901confirmatory gene. The results of the broth microdilution method revealed that most of the recovered isolates exhibited multidrug resistance (MDR) to isoniazid, rifampicin, streptomycin, oxytetracycline, and doxycycline, and harbored the inhA, rpoB, rpsL, and otrB genes.
conclusionIn brief, to the best of our knowledge this is the first report that emphasized the emergence of avian tuberculosis in house-reared domestic birds in Egypt. The emergence of MDR- M. avium subsp. avium is considered a public health threat. Emerging MDR-M. avium subsp. avium in domestic birds are commonly harbored the IS901, inhA, rpoB, rpsL, and otrB genes. Azithromycin and clofazimine revealed a promising in-vitro antibacterial activity against M. avium subsp. avium.
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