Evidence map›Paper›PMID 34445919›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Microwave-assisted Phospha-Michael addition reactions in the 13α-oestrone series and

Erzsébet Mernyák, Sándor Bartha, Lili Kóczán, Rebeka Jójárt, Vivien Resch, Gábor Paragi, Máté Vágvölgyi, Attila Hunyadi, Bella Bruszel, István Zupkó and 1 more

Abstract read
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In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Erzsébet MernyákDepartment of Organic Chemistry, University of Szeged, Szeged, Hungary.
Sándor BarthaDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
Lili KóczánDepartment of Organic Chemistry, University of Szeged, Szeged, Hungary.
Rebeka JójártDepartment of Organic Chemistry, University of Szeged, Szeged, Hungary.
Vivien ReschDepartment of Medicinal Chemistry, University of Szeged, Szeged, Hungary.
Gábor ParagiMTA-SZTE Biomimetic Systems Research Group, University of Szeged, Szeged, Hungary.
Máté VágvölgyiDepartment of Pharmacognosy, University of Szeged, Szeged, Hungary.
Attila HunyadiDepartment of Pharmacognosy, University of Szeged, Szeged, Hungary.
Bella BruszelDepartment of Medicinal Chemistry, University of Szeged, Szeged, Hungary.
István ZupkóDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
Renáta MinoricsDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microwave-assisted phospha-Michael addition reactions were carried out in the 13α-oestrone series. The exocyclic 16-methylene-17-ketones as α,β-unsaturated ketones were reacted with secondary phosphine oxides as nucleophilic partners. The addition reactions furnished the two tertiary phosphine oxide diastereomers in high yields. The main product was the 16α-isomer. The antiproliferative activities of the newly synthesised organophosphorus compounds against a panel of nine human cancer cell lines were investigated by means of MTT assays. The most potent compound, the diphenylphosphine oxide derivative in the 3-

Indexed as

AnimalsAntineoplastic AgentsCell LineCell ProliferationDrug Screening Assays, AntitumorEstroneFibroblastsHumansMiceMicrowavesModels, MolecularOrganophosphorus CompoundsPhosphinesStructure-Activity RelationshipAntineoplastic AgentsEstroneOrganophosphorus CompoundsphosphinePhosphinestriphenylphosphine oxide13α-oestroneantiproliferative effectPhospha-Michael additiontumour selectivityα,β-unsaturated ketone

Identifiers

PMID34445919
PMCPMC8405091

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.