Evidence map›Paper›PMID 34445875›Full record

ArticleJournal of natural products2021

Functional Characterization of the Nemertide α Family of Peptide Toxins.

Erik Jacobsson, Steve Peigneur, Håkan S Andersson, Quentin Laborde, Malin Strand, Jan Tytgat, Ulf Göransson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Erik JacobssonPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 591, SE-751 24, Uppsala, Sweden.
Steve PeigneurToxicology & Pharmacology, University of Leuven (KU Leuven), O&N 2, PO Box 992, Herestraat 49, 3000, Leuven, Belgium.
Håkan S AnderssonPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 591, SE-751 24, Uppsala, Sweden.
Quentin LabordePharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 591, SE-751 24, Uppsala, Sweden.
Malin StrandSwedish Species Information Centre, Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden.
Jan TytgatToxicology & Pharmacology, University of Leuven (KU Leuven), O&N 2, PO Box 992, Herestraat 49, 3000, Leuven, Belgium.
Ulf GöranssonPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Box 591, SE-751 24, Uppsala, Sweden.ORCID 0000-0002-5005-9612
Uppsala University · SEKU Leuven · BESwedish University of Agricultural Sciences · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptide toxins find use in medicine, biotechnology, and agriculture. They are exploited as pharmaceutical tools, particularly for the investigation of ion channels. Here, we report the synthesis and activity of a novel family of peptide toxins: the cystine-knotted α nemertides. Following the prototypic α-1 and -2 (

Indexed as

Amino Acid SequenceAnimalsArtemiaCockroachesInvertebratesPeptidesProtein FoldingProtein Structure, TertiaryStructure-Activity RelationshipToxins, BiologicalVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium ChannelsPeptidesToxins, BiologicalVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium Channels

Identifiers

PMID34445875
PMCPMC8406415
OpenAlexW2970691515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.