Evidence map›Paper›PMID 34445792›Full record

ArticleInternational journal of molecular sciences2021

Natural Mutations Affect Structure and Function of gC1q Domain of Otolin-1.

Rafał Hołubowicz, Andrzej Ożyhar, Piotr Dobryszycki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Assortment of Frontiers in Protein Science.International journal of molecular sciences · 2022
    Article
  3. Article
  4. Advances in otolith-related protein research.Frontiers in neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rafał HołubowiczDepartment of Biochemistry, Molecular Biology and Biotechnology, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.ORCID 0000-0002-2555-2069
Andrzej OżyharDepartment of Biochemistry, Molecular Biology and Biotechnology, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.ORCID 0000-0002-5874-784X
Piotr DobryszyckiDepartment of Biochemistry, Molecular Biology and Biotechnology, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.
Wrocław University of Science and Technology · PL

Funding

Narodowym Centrum Nauki 2017/27/N/NZ1/01319
6 · The paper itself

Abstract

Otolin-1 is a scaffold protein of otoliths and otoconia, calcium carbonate biominerals from the inner ear. It contains a gC1q domain responsible for trimerization and binding of Ca

Indexed as

Amino Acid SequenceBenign Paroxysmal Positional VertigoCalciumCalcium-Binding ProteinsExtracellular Matrix ProteinsHumansMutationProtein DomainsCalciumCalcium-Binding ProteinsExtracellular Matrix Proteinsotolin-1analytical ultracentrifugationC1qcalcium binding proteinscircular dichroismgenetic variationotoconiaOTOL1otolin-1site-directed mutagenesisthermal shift assay

Identifiers

PMID34445792
PMCPMC8396674
OpenAlexW3193488009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.