Evidence map›Paper›PMID 34445761›Full record

ArticleInternational journal of molecular sciences2021

Combining OSMAC Approach and Untargeted Metabolomics for the Identification of New Glycolipids with Potent Antiviral Activity Produced by a Marine

Fortunato Palma Esposito, Rosa Giugliano, Gerardo Della Sala, Giovanni Andrea Vitale, Carmine Buonocore, Janardhan Ausuri, Christian Galasso, Daniela Coppola, Gianluigi Franci, Massimiliano Galdiero and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

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  16. Biotechnological potentials of halophilic microorganisms and their impact on mankind.Beni-Suef University journal of basic and applied sciences · 2022
    Review
  17. Frontiers in microbiology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Fortunato Palma EspositoDepartment of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0002-3768-4712
Rosa GiuglianoDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-9923-3194
Gerardo Della SalaDepartment of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0001-8957-3259
Giovanni Andrea VitaleDepartment of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Carmine BuonocoreDepartment of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0002-8327-954X
Janardhan AusuriInstitute of Biochemistry and Cell Biology, National Research Council, 80131 Naples, Italy.ORCID 0000-0002-2017-7482
Christian GalassoDepartment of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0002-1262-959X
Daniela CoppolaDepartment of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0001-6699-8967
Gianluigi FranciDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.ORCID 0000-0003-3321-4331
Massimiliano GaldieroDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1576-6290
Donatella de PascaleDepartment of Marine Biotechnology Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
Stazione Zoologica Anton Dohrn · ITUniversity of Campania "Luigi Vanvitelli" · ITNational Research Council · ITUniversity of Salerno · IT

Funding

H2020 Societal Challenges 101000794
6 · The paper itself

Abstract

Natural products of microbial origin have inspired most of the commercial pharmaceuticals, especially those from Actinobacteria. However, the redundancy of molecules in the discovery process represents a serious issue. The untargeted approach, One Strain Many Compounds (OSMAC), is one of the most promising strategies to induce the expression of silent genes, especially when combined with genome mining and advanced metabolomics analysis. In this work, the whole genome of the marine isolate

Indexed as

AnimalsAntiviral AgentsChlorocebus aethiopsCulture TechniquesDrug Screening Assays, AntitumorEstersGenome, BacterialGlycolipidsHumansMetabolomeMicrobial Sensitivity TestsMolecular StructurePC-3 CellsRhodococcusSuccinatesSurface-Active AgentsAntiviral AgentsEstersGlycolipidsSuccinatesSurface-Active Agentsantiproliferativeantiviralbiosurfactantglycolipidsmarine bacteriamass spectrometrymetabolomicsmicrobial natural productsOSMAC approachtrehalolipids

Identifiers

PMID34445761
PMCPMC8396431
OpenAlexW3194835549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.