Evidence map›Paper›PMID 34445716›Full record

ArticleInternational journal of molecular sciences2021

Photopharmacological Applications for Cherenkov Radiation Generated by Clinically Used Radionuclides.

Melanie Krebs, Alexander Döbber, Theo Rodat, Ulf Lützen, Yi Zhao, Maaz Zuhayra, Christian Peifer

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Melanie KrebsInstitute of Pharmacy, Christian-Albrechts-University of Kiel, Gutenbergstraße 76, 24118 Kiel, Germany.
Alexander DöbberInstitute of Pharmacy, Christian-Albrechts-University of Kiel, Gutenbergstraße 76, 24118 Kiel, Germany.
Theo RodatInstitute of Pharmacy, Christian-Albrechts-University of Kiel, Gutenbergstraße 76, 24118 Kiel, Germany.
Ulf LützenClinic for Nuclear Medicine, Molecular Image Diagnostics and Therapy, Arnold-Heller-Straße, 24105 Kiel, Germany.
Yi ZhaoClinic for Nuclear Medicine, Molecular Image Diagnostics and Therapy, Arnold-Heller-Straße, 24105 Kiel, Germany.
Maaz ZuhayraClinic for Nuclear Medicine, Molecular Image Diagnostics and Therapy, Arnold-Heller-Straße, 24105 Kiel, Germany.
Christian PeiferInstitute of Pharmacy, Christian-Albrechts-University of Kiel, Gutenbergstraße 76, 24118 Kiel, Germany.ORCID 0000-0003-1532-7826

Funding

Deutsche Forschungsgemeinschaft PE1605_2_2
6 · The paper itself

Abstract

Translational photopharmacological applications are limited through irradiation by light showing wavelengths within the bio-optical window. To achieve sufficient tissue penetration, using wavelengths >500 nm is mandatory. Nevertheless, the majority of photopharmacological compounds respond to irradiation with more energetic UV light, which shows only a minor depth of tissue penetration in the µm range. Thus, we became interested in UV light containing Cherenkov radiation (CR) induced as a by-product by clinically employed radionuclides labeling specific tissues. Therefore, CR may be applicable in novel photopharmacological approaches. To provide evidence for the hypothesis, we verified the clinically established radionuclides

Indexed as

Fluorine RadioisotopesGallium RadioisotopesLuminescent ProteinsPhototherapyRadioisotopesRadiopharmaceuticalsUltraviolet RaysUltraviolet TherapyYttrium RadioisotopesFluorine RadioisotopesGallium RadioisotopesLuminescent ProteinsRadioisotopesRadiopharmaceuticalsYttrium Radioisotopesbio-optical windowCDK2Cherenkov radiationkinase inhibitorphotopharmacologyradionuclides

Identifiers

PMID34445716
PMCPMC8396513

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.