Evidence map›Paper›PMID 34445711›Full record

ReviewInternational journal of molecular sciences2021

Angioedema and Fatty Acids.

Akane Wada, Yu Sawada, Hitomi Sugino, Motonobu Nakamura

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Mast cell mediators in hereditary angioedema.Orphanet journal of rare diseases · 2026
    Article
  2. Article
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Akane WadaDepartment of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, Japan.
Yu SawadaDepartment of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, Japan.
Hitomi SuginoDepartment of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, Japan.
Motonobu NakamuraDepartment of Dermatology, Faculty of Medicine, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanisi-Ku, Kitakyushu, Fukuoka 807-8555, Japan.
University of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angioedema is a life-threatening emergency event that is associated with bradykinin and histamine-mediated cascades. Although bradykinin-mediated angioedema currently has specific therapeutic options, angioedema is sometimes intractable with current treatments, especially histamine-mediated angioedema, suggesting that some other mediators might contribute to the development of angioedema. Fatty acids are an essential fuel and cell component, and act as a mediator in physiological and pathological human diseases. Recent updates of studies revealed that these fatty acids are involved in vascular permeability and vasodilation, in addition to bradykinin and histamine-mediated reactions. This review summarizes each fatty acid's function and the specific receptor signaling responses in blood vessels, and focuses on the possible pathogenetic role of fatty acids in angioedema.

Indexed as

AngioedemaBradykininCapillary PermeabilityFatty AcidsHistamineHumansProstaglandinsBradykininFatty AcidsHistamineProstaglandinsangioedemafatty acidshereditary angioedema

Identifiers

PMID34445711
PMCPMC8396478
OpenAlexW3195356033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.