Evidence map›Paper›PMID 34445704›Full record

ArticleInternational journal of molecular sciences2021

Pumilio2 Promotes Growth of Mature Neurons.

Rico Schieweck, Elisa-Charlott Schöneweiss, Max Harner, Daniela Rieger, Christin Illig, Barbara Saccà, Bastian Popper, Michael A Kiebler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Function of GSK‑3 signaling in spinal cord injury (Review).Experimental and therapeutic medicine · 2023
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rico SchieweckBiomedical Center (BMC), Department for Cell Biology & Anatomy, Medical Faculty, Ludwig-Maximilians-University, 82152 München, Germany.
Elisa-Charlott SchöneweissZentrum für Medizinische Biotechnologie (ZMB), University of Duisburg-Essen, 41541 Duisburg, Germany.
Max HarnerBiomedical Center (BMC), Department for Cell Biology & Anatomy, Medical Faculty, Ludwig-Maximilians-University, 82152 München, Germany.
Daniela RiegerBiomedical Center (BMC), Department for Cell Biology & Anatomy, Medical Faculty, Ludwig-Maximilians-University, 82152 München, Germany.
Christin IlligBiomedical Center (BMC), Department for Cell Biology & Anatomy, Medical Faculty, Ludwig-Maximilians-University, 82152 München, Germany.
Barbara SaccàZentrum für Medizinische Biotechnologie (ZMB), University of Duisburg-Essen, 41541 Duisburg, Germany.ORCID 0000-0003-2708-2272
Bastian PopperBiomedical Center (BMC), Department for Cell Biology & Anatomy, Medical Faculty, Ludwig-Maximilians-University, 82152 München, Germany.ORCID 0000-0003-1517-695X
Michael A KieblerBiomedical Center (BMC), Department for Cell Biology & Anatomy, Medical Faculty, Ludwig-Maximilians-University, 82152 München, Germany.ORCID 0000-0002-8850-6297
Ludwig-Maximilians-Universität München · DEUniversity of Duisburg-Essen · DE

Funding

Boehringer Ingelheim Fonds to RSDeutsche Forschungsgemeinschaft FOR2333 to MAKDeutsche Forschungsgemeinschaft SPP1738 to MAKFriedrich-Baur-Stiftung 02/14 to BP
6 · The paper itself

Abstract

RNA-binding proteins (RBPs) are essential regulators controlling both the cellular transcriptome and translatome. These processes enable cellular plasticity, an important prerequisite for growth. Cellular growth is a complex, tightly controlled process. Using cancer cells as model, we looked for RBPs displaying strong expression in published transcriptome datasets. Interestingly, we found the Pumilio (Pum) protein family to be highly expressed in all these cells. Moreover, we observed that Pum2 is regulated by basic fibroblast growth factor (bFGF). bFGF selectively enhances protein levels of Pum2 and the eukaryotic initiation factor 4E (eIF4E). Exploiting atomic force microscopy and in vitro pulldown assays, we show that Pum2 selects for

Indexed as

AnimalsEukaryotic Initiation Factor-4EFemaleFibroblast Growth Factor 2Gene ExpressionMaleMiceMice, Inbred C57BLMicroscopy, Atomic ForceNeurogenesisNeuronsProtein BindingRNA-Binding ProteinsRNA, MessengerTranscriptomeeIF4E protein, mouseEukaryotic Initiation Factor-4EFibroblast Growth Factor 2Pum2 protein, mouseRNA-Binding ProteinsRNA, Messengeratomic force microscopyeIF4Eneuronal growthPumilio2

Identifiers

PMID34445704
PMCPMC8396670
OpenAlexW3193588821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.