Evidence map›Paper›PMID 34445665›Full record

ReviewInternational journal of molecular sciences2021

Effects of Primary Mast Cell Disease on Hemostasis and Erythropoiesis.

Holger Seidel, Hans-Jörg Hertfelder, Johannes Oldenburg, Johannes P Kruppenbacher, Lawrence B Afrin, Gerhard J Molderings

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Stroke in a patient of anaphylaxis-a case report and brief review.International journal of emergency medicine · 2023
    Article
  9. Mast Cells in Human Health and Diseases.International journal of molecular sciences · 2023
    Article
  10. Article
  11. Review
  12. Coronary atherosclerosis and chemotherapy: From bench to bedside.Frontiers in cardiovascular medicine · 2023
    Review
  13. Metal Binding to Sodium Heparin Monitored by Quadrupolar NMR.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Holger SeidelCenter for Bleeding Disorders and Transfusion Medicine (CBT), Am Propsthof 3, D-53121 Bonn, Germany.ORCID 0000-0002-5337-3797
Hans-Jörg HertfelderCenter for Bleeding Disorders and Transfusion Medicine (CBT), Am Propsthof 3, D-53121 Bonn, Germany.
Johannes OldenburgInstitute of Experimental Haematology and Transfusion Medicine, University Hospital Bonn, Venusberg-Campus 1, D-53127 Bonn, Germany.ORCID 0000-0002-1585-4100
Johannes P KruppenbacherCenter for Bleeding Disorders and Transfusion Medicine (CBT), Am Propsthof 3, D-53121 Bonn, Germany.
Lawrence B AfrinDepartment of Mast Cell Studies, AIM Center for Personalized Medicine, 3010 Westchester Ave Suite 404, Purchase, NY 10577, USA.ORCID 0000-0003-3550-4244
Gerhard J MolderingsInstitute of Human Genetics, University Hospital of Bonn, Venusberg-Campus 1, D-53127 Bonn, Germany.
University Hospital Bonn · DEAbilities In Motion · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mast cell disease is an epigenetically and genetically determined disease entity with very diverse clinical manifestations in potentially every system and tissue due to inap pro priate release of variable subsets of mast cell mediators together with accumulation of either morphologically normal or altered mast cells. Easy bruising, excessive bleeding, and aberrancies of erythropoiesis can frequently be observed in patients with mast cell disease. A thorough history, including a family history, will guide the appropriate work-up, and laboratory evaluations may provide clues to diagnosis. In recent years, our understanding of the involvement of coagulation and anticoagulant pathways, the fibrinolytic system, and erythropoiesis in the pathophysiology of mast cell disease has increased considerably. This review summarizes current knowledge of the impact of the disturbed hemostatic and erythropoietic balance in patients with mast cell disease and describes options of treatment.

Indexed as

AnticoagulantsBlood CoagulationErythropoiesisFibrinolysisFibrinolytic AgentsHemostasisHeparinHumansMastocytosisAnticoagulantsFibrinolytic AgentsHeparinbleedingerythropoiesisfibrinolysishemostasisheparinmast cell disease

Identifiers

PMID34445665
PMCPMC8396658
OpenAlexW3195772321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.