Evidence map›Paper›PMID 34445656›Full record

ArticleInternational journal of molecular sciences2021

Molecular Iodine/Cyclophosphamide Synergism on Chemoresistant Neuroblastoma Models.

Winniberg Álvarez-León, Irasema Mendieta, Evangelina Delgado-González, Brenda Anguiano, Carmen Aceves

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Molecular Iodine/Cells · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Winniberg Álvarez-LeónInstituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM) Juriquilla, Querétaro 76230, Mexico.
Irasema MendietaInstituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM) Juriquilla, Querétaro 76230, Mexico.
Evangelina Delgado-GonzálezInstituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM) Juriquilla, Querétaro 76230, Mexico.ORCID 0000-0003-2605-4632
Brenda AnguianoInstituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM) Juriquilla, Querétaro 76230, Mexico.
Carmen AcevesInstituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM) Juriquilla, Querétaro 76230, Mexico.ORCID 0000-0001-9418-8304
Universidad Nacional Autónoma de México · MX

Funding

PAPIIT-UNAM 203919PAPIIT-UNAM 205920
6 · The paper itself

Abstract

Neuroblastoma (Nb), the most common extracranial tumor in children, exhibited remarkable phenotypic diversity and heterogeneous clinical behavior. Tumors with MYCN overexpression have a worse prognosis. MYCN promotes tumor progression by inducing cell proliferation, de-differentiation, and dysregulated mitochondrial metabolism. Cyclophosphamide (CFF) at minimum effective oral doses (metronomic therapy) exerts beneficial actions on chemoresistant cancers. Molecular iodine (I

Indexed as

Drug SynergismAnimalsAnti-Infective Agents, LocalAntineoplastic Agents, AlkylatingApoptosisBiomarkers, TumorCell DifferentiationCell ProliferationCyclophosphamideDrug Resistance, NeoplasmDrug Therapy, CombinationGene Expression Regulation, NeoplasticHumansIodineMaleMiceAnti-Infective Agents, LocalAntineoplastic Agents, AlkylatingBiomarkers, TumorCyclophosphamideIodinecyclophosphamidemetronomic therapymolecular iodineneuroblastomaxenografts

Identifiers

PMID34445656
PMCPMC8396562
OpenAlexW3194097069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.