Evidence map›Paper›PMID 34445652›Full record

ArticleInternational journal of molecular sciences2021

Thresholds of Endoglin Expression in Endothelial Cells Explains Vascular Etiology in Hereditary Hemorrhagic Telangiectasia Type 1.

Georgios Galaris, Kévin Montagne, Jérémy H Thalgott, Geoffroy J P E Goujon, Sander van den Driesche, Sabrina Martin, Hans-Jurgen J Mager, Christine L Mummery, Ton J Rabelink, Franck Lebrin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Case report: Novel homozygousFrontiers in genetics · 2025
    Article
  5. Article
  6. Blood flow regulatesbioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Georgios GalarisEinthoven Laboratory for Experimental Vascular Medicine, Department of Internal Medicine (Nephrology), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Kévin MontagneDepartment of Mechanical Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8654, Japan.
Jérémy H ThalgottEinthoven Laboratory for Experimental Vascular Medicine, Department of Internal Medicine (Nephrology), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-0485-4025
Geoffroy J P E GoujonEinthoven Laboratory for Experimental Vascular Medicine, Department of Internal Medicine (Nephrology), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Sander van den DriescheCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.ORCID 0000-0002-8092-6588
Sabrina MartinCenter for Interdisciplinary Research in Biology (CIRB), UMR7241/U1050, 75005 Paris, France.
Hans-Jurgen J MagerDepartment of Pulmonology, St Antonius Hospital, 3435 CM Nieuwegein, The Netherlands.
Christine L MummeryDepartment of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-4549-6535
Ton J RabelinkEinthoven Laboratory for Experimental Vascular Medicine, Department of Internal Medicine (Nephrology), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Franck LebrinEinthoven Laboratory for Experimental Vascular Medicine, Department of Internal Medicine (Nephrology), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-1650-6757
Leiden University Medical Center · NLCentre Interdisciplinaire de Recherche en Biologie · FRCentre National de la Recherche Scientifique · FRSt. Antonius Ziekenhuis · NLThe University of Tokyo · JPZhejiang University-University of Edinburgh Institute · CN

Funding

Agence Nationale de la Recherche ANR-2010-JCJC-1112-01Health~Holland LSHM19057- HHT-Pi3KZonMw PTO446002501
6 · The paper itself

Abstract

Hereditary Hemorrhagic Telangiectasia type 1 (HHT1) is an autosomal dominant inherited disease characterized by arteriovenous malformations and hemorrhage. HHT1 is caused by mutations in

Indexed as

MutationAnimalsEndoglinEndothelium, VascularMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionTelangiectasia, Hereditary HemorrhagicVascular DiseasesEndoglinEng protein, mousecell signalingendoglinendothelial cellshereditary hemorrhagic telangiectasia

Identifiers

PMID34445652
PMCPMC8396348
OpenAlexW3194965929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.