Evidence map›Paper›PMID 34445631›Full record

ArticleInternational journal of molecular sciences2021

Genetic Variants and Tumor Immune Microenvironment: Clues for Targeted Therapies in Inflammatory Breast Cancer (IBC).

Yulan Gong, Rajeswari Nagarathinam, Maria F Arisi, Lorenzo Gerratana, Jennifer S Winn, Michael Slifker, Jianming Pei, Kathy Q Cai, Zachary Hasse, Elias Obeid and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Yulan GongFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Rajeswari NagarathinamFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Maria F ArisiDepartment of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Lorenzo GerratanaFeinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-8313-4834
Jennifer S WinnFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Michael SlifkerFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Jianming PeiFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Kathy Q CaiFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Zachary HasseFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Elias ObeidFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Julio NoriegaFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Christopher SebastianoDepartment of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Eric RossFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Katherine AlpaughFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Massimo CristofanilliFeinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Sandra V FernandezFox Chase Cancer Center, Philadelphia, PA 19111, USA.ORCID 0000-0002-5859-963X
Fox Chase Cancer Center · USNorthwestern University · USThomas Jefferson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To better understand the etiology of inflammatory breast cancer (IBC) and identify potential therapies, we studied genomic alterations in IBC patients. Targeted, next-generation sequencing (NGS) was performed on cell-free DNA (cfDNA) (

Indexed as

Molecular Targeted TherapyMutationAdultAgedB7-H1 AntigenBiomarkers, TumorCell-Free Nucleic AcidsErb-b2 Receptor Tyrosine KinasesFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHigh-Throughput Nucleotide SequencingHumansInflammatory Breast NeoplasmsLymphocytes, Tumor-InfiltratingMiddle AgedB7-H1 AntigenBiomarkers, TumorCD274 protein, humanCell-Free Nucleic AcidsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesReceptors, EstrogenReceptors, Progesteronecell-free DNA (cfDNA)immune checkpoint inhibitors (ICIs)PARP inhibitorpoly (ADP-ribose) polymeraseprogrammed cell death-ligand 1 (PD-L1)tumor infiltrating lymphocytes (TILs)

Identifiers

PMID34445631
PMCPMC8396191
OpenAlexW3194196346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.