Evidence map›Paper›PMID 34445628›Full record

ArticleInternational journal of molecular sciences2021

Hippocampal and Reticulo-Thalamic Parvalbumin Interneurons and Synaptic Re-Organization during Sleep Disorders in the Rat Models of Parkinson's Disease Neuropathology.

Ljiljana Radovanovic, Jelena Petrovic, Jasna Saponjic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ljiljana RadovanovicInstitute for Biological Research "Sinisa Stankovic", National Institute of Republic of Serbia, Department of Neurobiology, University of Belgrade, 11060 Belgrade, Serbia.
Jelena PetrovicInstitute for Biological Research "Sinisa Stankovic", National Institute of Republic of Serbia, Department of Neurobiology, University of Belgrade, 11060 Belgrade, Serbia.
Jasna SaponjicInstitute for Biological Research "Sinisa Stankovic", National Institute of Republic of Serbia, Department of Neurobiology, University of Belgrade, 11060 Belgrade, Serbia.ORCID 0000-0002-6903-9056
University of Belgrade · RS

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-9/2021-14/ 200007
6 · The paper itself

Abstract

We investigated the alterations of hippocampal and reticulo-thalamic (RT) GABAergic parvalbumin (PV) interneurons and their synaptic re-organizations underlying the prodromal local sleep disorders in the distinct rat models of Parkinson's disease (PD). We demonstrated for the first time that REM sleep is a predisposing state for the high-voltage sleep spindles (HVS) induction in all experimental models of PD, particularly during hippocampal REM sleep in the hemiparkinsonian models. There were the opposite underlying alterations of the hippocampal and RT GABAergic PV+ interneurons along with the distinct MAP2 and PSD-95 expressions. Whereas the PD cholinopathy enhanced the number of PV+ interneurons and suppressed the MAP2/PSD-95 expression, the hemiparkinsonism with PD cholinopathy reduced the number of PV+ interneurons and enhanced the MAP2/PSD-95 expression in the hippocampus. Whereas the PD cholinopathy did not alter PV+ interneurons but partially enhanced MAP2 and suppressed PSD-95 expression remotely in the RT, the hemiparkinsonism with PD cholinopathy reduced the PV+ interneurons, enhanced MAP2, and did not change PSD-95 expression remotely in the RT. Our study demonstrates for the first time an important regulatory role of the hippocampal and RT GABAergic PV+ interneurons and the synaptic protein dynamic alterations in the distinct rat models of PD neuropathology.

Indexed as

Disease Models, AnimalAnimalsDisks Large Homolog 4 Proteingamma-Aminobutyric AcidHippocampusInterneuronsMaleMicrotubule-Associated ProteinsNeuropathologyParkinson DiseaseParvalbuminsRatsRats, WistarReticular FormationSleep Wake DisordersSynapsesDisks Large Homolog 4 ProteinDlg4 protein, ratgamma-Aminobutyric AcidMAP2 protein, ratMicrotubule-Associated ProteinsParvalbuminshippocampusmicrotubule-associated protein 2 (MAP2)Parkinson’s diseaseparvalbumin-expressing interneuronspostsynaptic density protein 95 (PSD-95)prodromal sleep disordersratreticulo-thalamic nucleussleep spindle dynamics

Identifiers

PMID34445628
PMCPMC8396216
OpenAlexW3193625058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.