Evidence map›Paper›PMID 34445623›Full record

ArticleInternational journal of molecular sciences2021

Effect of 9,12-Octadecadiynoic Acid on Neurobehavioral Development in

Tun-Chieh Chen, How-Ran Chao, Ching-Ying Wu, Yun-Ru Lai, Chu-Huang Chen, Tohru Yoshioka, Wen-Li Hsu, Ming-Hsien Tsai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Tun-Chieh ChenDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, No. 68, Jhonghua 3rd Rd, Cianjin District, Kaohsiung 80145, Taiwan.ORCID 0000-0002-9258-0692
How-Ran ChaoDepartment of Environmental Science and Engineering, College of Engineering, National Pingtung University of Science and Technology, No.1, Shuefu Road, Pingtung 91201, Taiwan.ORCID 0000-0001-6492-6417
Ching-Ying WuDepartment of Dermatology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 68, Jhonghua 3rd Rd, Cianjin District, Kaohsiung 80145, Taiwan.
Yun-Ru LaiRegenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.
Chu-Huang ChenVascular and Medicinal Research, Texas Heart Institute, 6770 Bertner Avenue, Houston, TX 77030, USA.
Tohru YoshiokaRegenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.
Wen-Li HsuDepartment of Dermatology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 68, Jhonghua 3rd Rd, Cianjin District, Kaohsiung 80145, Taiwan.ORCID 0000-0003-1034-4977
Ming-Hsien TsaiRegenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.
Kaohsiung Medical University · TWChang Gung University of Science and Technology · TWNational Pingtung University of Science and Technology · TWShinshu University · JP

Funding

Kaohsiung Municipal Ta-Tung Hospital kmtth-104-019, kmtth-107-045, kmtth-109-001, kmtth-109-030Ministry of Science and Technology MOST 108-2314-B-020-001, MOST 109-2314-B-020-001, MOST 109-2314-B-037-143
6 · The paper itself

Abstract

Human breast milk lipids have major beneficial effects: they promote infant early brain development, growth and health. To identify the relationship between human breast milk lipids and infant neurodevelopment, multivariate analyses that combined lipidomics and psychological Bayley-III scales evaluation were utilized. We identified that 9,12-octadecadiynoic acid has a significantly positive correlation with infant adaptive behavioral development, which is a crucial neurodevelopment to manage risk from environmental stress. To further clarify the biological function of 9,12-octadecadiynoic acid in regulating neurodevelopment,

Indexed as

AnimalsBehavior, AnimalCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression Regulation, DevelopmentalLarvaLinoleic AcidNervous SystemOxidative StressCaenorhabditis elegans ProteinsLinoleic Acid9,12-octadecadiynoic acidadaptive behaviorCaenorhabditis eleganshuman breast milklipidomicsneurodevelopment

Identifiers

PMID34445623
PMCPMC8396327
OpenAlexW3193985598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.