Evidence map›Paper›PMID 34445619›Full record

ReviewInternational journal of molecular sciences2021

Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia.

Sachiko Koyama, Kenji Kondo, Rumi Ueha, Hideki Kashiwadani, Thomas Heinbockel

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Utilization of Cannabidiol in Post-Organ-Transplant Care.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Intranasal insulin for COVID-19-related smell loss.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sachiko KoyamaDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0002-6886-1961
Kenji KondoDepartment of Otolaryngology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Rumi UehaDepartment of Otolaryngology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.ORCID 0000-0002-0608-7237
Hideki KashiwadaniDepartment of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.ORCID 0000-0001-8267-6626
Thomas HeinbockelDepartment of Anatomy, College of Medicine, Howard University, Washington, DC 20059, USA.ORCID 0000-0003-4347-2131

Funding

SWG 2: Cure Research Scientific Working GroupP30AI117970 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Italo Mocchetti · 2015 to 2026
$29.6M
National Science Foundation NSF IOS-1355034NIAID NIH HHS P30 AI117970NIH HHS P30AI117970
6 · The paper itself

Abstract

The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms of the SARS-CoV-2 disease, COVID-19, is the loss of chemical senses, i.e., smell and taste. Smell training is one of the methods used in facilitating recovery of the olfactory sense, and it uses essential oils of lemon, rose, clove, and eucalyptus. These essential oils were not selected based on their chemical constituents. Although scientific studies have shown that they improve recovery, there may be better combinations for facilitating recovery. Many phytochemicals have bioactive properties with anti-inflammatory and anti-viral effects. In this review, we describe the chemical compounds with anti- inflammatory and anti-viral effects, and we list the plants that contain these chemical compounds. We expand the review from terpenes to the less volatile flavonoids in order to propose a combination of essential oils and diets that can be used to develop a new taste training method, as there has been no taste training so far. Finally, we discuss the possible use of these in clinical settings.

Indexed as

COVID-19 Drug TreatmentAgeusiaAnosmiaCOVID-19HumansPhytochemicalsSARS-CoV-2Phytochemicalsageusiaanosmiaanti-inflammatory effectsanti-viral effectsCOVID-19dietsessential oilsphytochemicalssmell trainingtaste training

Identifiers

PMID34445619
PMCPMC8396277

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.