Evidence map›Paper›PMID 34445614›Full record

ArticleInternational journal of molecular sciences2021

Palmitoylation of Prolactin-Releasing Peptide Increased Affinity for and Activation of the GPR10, NPFF-R2 and NPFF-R1 Receptors: In Vitro Study.

Alena Karnošová, Veronika Strnadová, Lucie Holá, Blanka Železná, Jaroslav Kuneš, Lenka Maletínská

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alena KarnošováBiochemistry and Molecular Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Veronika StrnadováBiochemistry and Molecular Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Lucie HoláBiochemistry and Molecular Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Blanka ŽeleznáBiochemistry and Molecular Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Jaroslav KunešBiochemistry and Molecular Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Lenka MaletínskáBiochemistry and Molecular Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 16610 Prague, Czech Republic.
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZCzech Academy of Sciences · CZCzech Academy of Sciences, Institute of Physiology · CZ

Funding

Akademie Věd České Republiky RVO:67985823Grantová Agentura České Republiky 21-03691SÚstav organické chemie a biochemie Akademie věd České republiky RVO:61388963
6 · The paper itself

Abstract

The anorexigenic neuropeptide prolactin-releasing peptide (PrRP) is involved in the regulation of food intake and energy expenditure. Lipidization of PrRP stabilizes the peptide, facilitates central effect after peripheral administration and increases its affinity for its receptor, GPR10, and for the neuropeptide FF (NPFF) receptor NPFF-R2. The two most potent palmitoylated analogs with anorectic effects in mice, palm

Indexed as

LipoylationAnimalsCalciumCHO CellsCricetinaeCricetulusHumansIn Vitro TechniquesProlactin-Releasing HormoneReceptors, G-Protein-CoupledReceptors, NeuropeptideCalciumneuropeptide FF receptorPRLH protein, humanPRLHR protein, humanProlactin-Releasing HormoneReceptors, G-Protein-CoupledReceptors, Neuropeptidebinding propertiesGPR10neuropeptide FFNPFF-R1NPFF-R2prolactin-releasing peptidesignaling pathways

Identifiers

PMID34445614
PMCPMC8396344
OpenAlexW3195842245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.