Evidence map›Paper›PMID 34445612›Full record

ArticleInternational journal of molecular sciences2021

Analysis of Several Pathways for Efficient Killing of Prostate Cancer Stem Cells: A Central Role of NF-κB RELA.

Kaya E Witte, Jesco Pfitzenmaier, Jonathan Storm, Melanie Lütkemeyer, Clara Wimmer, Wiebke Schulten, Nele Czaniera, Marvin Geisler, Christine Förster, Ludwig Wilkens and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Kaya E WitteDepartment of Cell Biology, University of Bielefeld, Universitätsstrasse 25, 33615 Bielefeld, Germany.ORCID 0000-0001-9300-3355
Jesco PfitzenmaierForschungsverbund BioMedizin Bielefeld, OWL (FBMB e.V.), Maraweg 21, 33617 Bielefeld, Germany.
Jonathan StormDepartment of Cell Biology, University of Bielefeld, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Melanie LütkemeyerDepartment of Cell Biology, University of Bielefeld, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Clara WimmerDepartment of Cell Biology, University of Bielefeld, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Wiebke SchultenDepartment of Cell Biology, University of Bielefeld, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Nele CzanieraDepartment of Cell Biology, University of Bielefeld, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Marvin GeislerDepartment of Cell Biology, University of Bielefeld, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Christine FörsterForschungsverbund BioMedizin Bielefeld, OWL (FBMB e.V.), Maraweg 21, 33617 Bielefeld, Germany.
Ludwig WilkensForschungsverbund BioMedizin Bielefeld, OWL (FBMB e.V.), Maraweg 21, 33617 Bielefeld, Germany.
Cornelius KnabbeForschungsverbund BioMedizin Bielefeld, OWL (FBMB e.V.), Maraweg 21, 33617 Bielefeld, Germany.
Fritz MertzlufftForschungsverbund BioMedizin Bielefeld, OWL (FBMB e.V.), Maraweg 21, 33617 Bielefeld, Germany.ORCID 0000-0003-0774-2739
Barbara KaltschmidtDepartment of Cell Biology, University of Bielefeld, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Jan Schulte Am EschForschungsverbund BioMedizin Bielefeld, OWL (FBMB e.V.), Maraweg 21, 33617 Bielefeld, Germany.
Christian KaltschmidtDepartment of Cell Biology, University of Bielefeld, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Bielefeld University · DEForschungsverbund Berlin · DEHeart and Diabetes Center North Rhine-Westphalia · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer is a common cause of death worldwide. Here, we isolated cancer stem cells (CSCs) from four adenocarcinomas of the prostate (Gleason scores from 3 + 3 up to 4 + 5). CSCs were characterized by the expression of the stem cell markers

Indexed as

Antibodies, Monoclonal, HumanizedAntineoplastic Agents, ImmunologicalApoptosisCell ProliferationGene Expression Regulation, NeoplasticHumansKiller Cells, NaturalMaleNeoplastic Stem CellsNF-kappa BProstatic NeoplasmsTumor Cells, CulturedTumor Necrosis Factor-alphaAntibodies, Monoclonal, HumanizedAntineoplastic Agents, ImmunologicalNF-kappa BpembrolizumabTumor Necrosis Factor-alphacancer stem cellsimmune checkpoint therapyinterferon gammamajor histocompatibility complex class Inatural killer cellsnuclear factor “kappa-light-chain-enhancer” of activated B-cellsprogrammed cell death 1 ligand 1 and -ligand 2prostate cancertumor necrosis factor

Identifiers

PMID34445612
PMCPMC8396252
OpenAlexW3195804053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.