Evidence map›Paper›PMID 34445585›Full record

ArticleInternational journal of molecular sciences2021

Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas.

Cheng-Ming Hsu, Ming-Yu Yang, Ming-Shao Tsai, Geng-He Chang, Yao-Hsu Yang, Yao-Te Tsai, Ching-Yuan Wu, Shun-Fu Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cheng-Ming HsuDepartment of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
Ming-Yu YangGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-6841-5478
Ming-Shao TsaiDepartment of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.ORCID 0000-0002-9314-5940
Geng-He ChangDepartment of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
Yao-Hsu YangDepartment of Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
Yao-Te TsaiDepartment of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
Ching-Yuan WuDepartment of Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
Shun-Fu ChangDepartment of Medical Research and Development, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.ORCID 0000-0002-2276-7785
Chiayi Chang Gung Memorial Hospital · TWChang Gung University · TW

Funding

Chang Gung Memorial Hospital CMRPG6G0421, CMRPG6G0422, CMRPG6G0423, CMRPG6J0251, and CMRPG6K0391
6 · The paper itself

Abstract

Head and neck squamous cell carcinomas (HNSCCs) are the most common cancers of the head and neck, and their prevalence is rapidly increasing. HNSCCs present a clinical challenge because of their high recurrence rate, therapeutic resistance to radiation and chemotherapy drugs, and adverse effects. Hence, traditional Chinese herbal treatment may be advantageous to therapeutic strategies for HNSCCs. Danshen (

Indexed as

AnimalsApoptosisCell ProliferationDrugs, Chinese HerbalHead and Neck NeoplasmsHumansMaleMiceMice, Inbred BALB CMice, NudePhenanthrenesSalvia miltiorrhizaSquamous Cell Carcinoma of Head and NeckTumor Cells, CulturedXenograft Model Antitumor Assaysdan-shen root extractdihydroisotanshinone IDrugs, Chinese HerbalPhenanthrenesapoptosisdanshendihydroisotanshinone Ihead and neck squamous cell carcinomap38 signalingSalvia miltiorrhiza

Identifiers

PMID34445585
PMCPMC8396193
OpenAlexW3196127228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.