Evidence map›Paper›PMID 34445574›Full record

ArticleInternational journal of molecular sciences2021

NMNAT1 Is a Survival Factor in Actinomycin D-Induced Osteosarcoma Cell Death.

Alexandra Kiss, Csaba Csikos, Zsolt Regdon, Zsuzsanna Polgár, László Virág, Csaba Hegedűs

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. The SIRT Family: Subcellular Localization and Main Functions.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Involvement ofFrontiers in oncology · 2025
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alexandra KissDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Csaba CsikosDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Zsolt RegdonDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-7682-2030
Zsuzsanna PolgárDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
László VirágDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-7099-6718
Csaba HegedűsDepartment of Medical Chemistry, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-8575-691X
University of Debrecen · HU

Funding

Bolyai postdoctoral fellowship BO/00468/17/8Debreceni Egyetem Bridging Fund 2020 (BFHC247)Emberi Eroforrások Minisztériuma EFOP-3.6.3-VEKOP-16-2017-511 00009Emberi Eroforrások Minisztériuma ÚNKP-19-4-DE-299Emberi Eroforrások Minisztériuma ÚNKP-20-3-II-DE-179.National Research, Development and Innovation Office GINOP-2.3.2-15-2016-00020 TUMORDNSNational Research, Development and Innovation Office GINOP-2.3.2-15-2016-00048-STAYALIVENational Research, Development and Innovation Office OTKA K132193National Research, Development and Innovation Office OTKA PD116845
6 · The paper itself

Abstract

Osteosarcoma is a frequent and extremely aggressive type of pediatric cancer. New therapeutic approaches are needed to improve the overall survival of osteosarcoma patients. Our previous results suggest that NMNAT1, a key enzyme in nuclear NAD

Indexed as

Gene Expression Regulation, NeoplasticAntibiotics, AntineoplasticApoptosisBiomarkers, TumorBone NeoplasmsCell ProliferationDactinomycinHumansNicotinamide-Nucleotide AdenylyltransferaseOsteosarcomaPoly (ADP-Ribose) Polymerase-1Sirtuin 1Tumor Cells, CulturedAntibiotics, AntineoplasticBiomarkers, TumorDactinomycinNicotinamide-Nucleotide AdenylyltransferaseNMNAT1 protein, humanPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1SIRT1 protein, humanSirtuin 1actinomycin Dapoptosiscancerchemotherapyhigh throughput screeningNAD+NMNAT1osteosarcomaPARP1SIRT1

Identifiers

PMID34445574
PMCPMC8396190
OpenAlexW3194524617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.