Evidence map›Paper›PMID 34445567›Full record

ArticleInternational journal of molecular sciences2021

Antagonizing S1P

Angela Corvino, Ida Cerqua, Alessandra Lo Bianco, Giuseppe Caliendo, Ferdinando Fiorino, Francesco Frecentese, Elisa Magli, Elena Morelli, Elisa Perissutti, Vincenzo Santagada and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Angela CorvinoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.ORCID 0000-0002-0617-156X
Ida CerquaDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.
Alessandra Lo BiancoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.ORCID 0000-0001-6408-8003
Giuseppe CaliendoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.
Ferdinando FiorinoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.ORCID 0000-0001-7357-5751
Francesco FrecenteseDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.ORCID 0000-0001-8821-2937
Elisa MagliDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.
Elena MorelliDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.
Elisa PerissuttiDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.ORCID 0000-0002-1754-1191
Vincenzo SantagadaDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.
Giuseppe CirinoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.
Elisabetta GranatoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.
Fiorentina RoviezzoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.
Elisa PulitiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale GB Morgagni 50, 50134 Firenze, Italy.
Caterina BernacchioniDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale GB Morgagni 50, 50134 Firenze, Italy.ORCID 0000-0002-1023-0067
Antonio LavecchiaDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.ORCID 0000-0002-2181-8026
Chiara DonatiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale GB Morgagni 50, 50134 Firenze, Italy.ORCID 0000-0003-2224-4199
Beatrice SeverinoDepartment of Pharmacy, School of Medicine, University of Naples «Federico II», Via D. Montesano 49, 80131 Napoli, Italy.ORCID 0000-0002-3887-8869
University of Naples Federico II · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

S1P is the final product of sphingolipid metabolism, which interacts with five widely expressed GPCRs (S1P

Indexed as

AnimalsCell-Penetrating PeptidesFibrosisMaleMiceMuscle, SkeletalMuscular DiseasesMyoblastsPeptide FragmentsReceptors, LysosphingolipidSphingosine-1-Phosphate ReceptorsCell-Penetrating Peptidesmyristoyl-glycyl-methionyl-arginyl-prolyl-tyrosyl-aspartyl-alanyl-asparagyl-lysyl-argininamidePeptide FragmentsReceptors, LysosphingolipidS1pr3 protein, mouseSphingosine-1-Phosphate Receptorsmolecular dynamics simulationsS1P3 receptor antagonistskeletal muscle fibrosissphingosine-1-phosphate

Identifiers

PMID34445567
PMCPMC8396189
OpenAlexW3193565243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.