ReviewInternational journal of molecular sciences2021
Vitamin D Deficiency, Osteoporosis and Effect on Autoimmune Diseases and Hematopoiesis: A Review.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Pooled it
- The Global Prevalence of Vitamin D Deficiency and Insufficiency in Patients with Multiple Myeloma: A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- Vitamin D Receptor (Nutrients · 2022Pooled it
- MMP2Mol: a matched molecular pairs-based framework for ligand-based de novo drug design.Briefings in bioinformatics · 2026Article
- 25-Hydroxyvitamin D Levels, Free Serum Calcium, Glomerular Filtration Rate, Albumin, and Femoral Fracture Elderly Patient Mortality.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Clinical Characteristics and Serum Vitamin D Levels in Patients with MRONJ Associated with Antiresorptive Therapy: A Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Article
- Association between uric acid to high-density lipoprotein cholesterol ratio (UHR) and osteoporosis in type 2 diabetes with MASLD.Asia Pacific journal of clinical nutrition · 2026Article
- Multinomial risk modeling of osteopenia and osteoporosis in Iraqi women: comparative contributions of osteoprotegerin and vitamin D3.Journal, genetic engineering & biotechnology · 2026Article
- Social Determinants of Health in Patients Undergoing Open Reduction and Internal Fixation for Distal Radius Fractures.Journal of wrist surgery · 2026Article
- Geriatric Nutritional Risk Index as a Predictor for Osteoporosis Risk in Elderly Patients with Type 2 Diabetes Mellitus: A Hospital-Based Study.Diagnostics (Basel, Switzerland) · 2026Article
- Serum 25-hydroxyvitamin D and health-related quality of life in patients with papillary thyroid carcinoma: a prospective cohort study.Frontiers in nutrition · 2026Article
- Vitamin D status in patients with arthritis and osteoporosis: a comparative analysis of inpatient and outpatient cohorts.Frontiers in endocrinology · 2026Article
- The relationship between nutrition status indicators and vitamin D deficiency in patients with type 2 diabetes mellitus.Frontiers in nutrition · 2026Article
- Beyond Calories: Addressing Micronutrient Deficiencies in the World's Most Vulnerable Communities-A Review.Nutrients · 2025Review
- The role of fat-soluble vitamins on bone metabolism and osteoporosis: a literature review.Annals of medicine · 2025Review
- IL-34 as a Novel Mediator Linking Vitamin D Deficiency with Osteoporosis and Knee Osteoarthritis.International journal of molecular sciences · 2025Article
- Defining the Tumor-Bone axis: the role of extracellular vesicles in a crucial exchange route for breast cancer development and progression.Clinical & experimental metastasis · 2025Review
- Vitamin D and bone health: from physiological function to disease association.Nutrition & metabolism · 2025Review
- Burden of screening and treatment of bone health markers amongst elderly patients with proximal femur fractures.Journal of orthopaedic surgery and research · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D (VD) is essential for bone homeostasis, but it is also involved in pleiotropic effects on various organs and tissues. In adults, VD deficiency can cause or exacerbate osteoporosis and induce osteomalacia. However, every tissue and cell in the body has a VD receptor, including the brain, heart, stomach, pancreas, skin, gonads, and immune cells, and a deficiency may modify the function of these organs. Thus, the wide-ranging actions of VD help to explain why a reduction in VD amount has been correlated with numerous chronic diseases. In fact, VD deficiency increases the risk of osteoporosis and several other diseases and complications characterized by impaired bone metabolisms, such as autoimmune diseases, inflammatory bowel diseases, allergy, endocrinological diseases, hematological malignancies, and bone marrow transplantation. This review aims to investigate the link between VD deficiency, osteoporosis, and its concomitant diseases. Further epidemiological and mechanistic studies are necessary in order to ascertain the real role of hypovitaminosis in causing the reported diseases; however, adequate vitamin supplementation and restoration of metabolic normality could be useful for better management of these pathologies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.