Evidence map›Paper›PMID 34445538›Full record

ArticleInternational journal of molecular sciences2021

Advanced Glycation End Products Are Retained in Decellularized Muscle Matrix Derived from Aged Skeletal Muscle.

Lucas C Olson, Tri M Nguyen, Rebecca L Heise, Barbara D Boyan, Zvi Schwartz, Michael J McClure

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Muscle Research: A Tour d'Horizon.International journal of molecular sciences · 2022
    Article
  11. Advanced Glycation End-Products in Skeletal Muscle Aging.Bioengineering (Basel, Switzerland) · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lucas C OlsonDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
Tri M NguyenDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
Rebecca L HeiseDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.ORCID 0000-0002-6602-6700
Barbara D BoyanDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
Zvi SchwartzDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
Michael J McClureDepartment of Biomedical Engineering, College of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
Virginia Commonwealth University · USGeorgia Institute of Technology · USThe University of Texas Health Science Center at San Antonio · US

Funding

Department of Defense W81XWH1810352Musculoskeletal Transplant Foundation J.R. Neff AwardMusculoskeletal Transplant Foundation Junior Investigator AwardNational Science Foundation 1351162
6 · The paper itself

Abstract

Decellularized tissues are biocompatible materials that engraft well, but the age of their source has not been explored for clinical translation. Advanced glycation end products (AGEs) are chemical cross-links that accrue on skeletal muscle collagen in old age, stiffening the matrix and increasing inflammation. Whether decellularized biomaterials derived from aged muscle would suffer from increased AGE collagen cross-links is unknown. We characterized gastrocnemii of 1-, 2-, and 20-month-old

Indexed as

AgingAnimalsCollagenExtracellular MatrixGlycation End Products, AdvancedMaleMiceMice, Inbred C57BLMuscle, SkeletalCollagenGlycation End Products, Advancedadvanced glycation end productscollagen cross-linkingdecellularizationskeletal muscle aging

Identifiers

PMID34445538
PMCPMC8396213
OpenAlexW3194772438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.