Evidence map›Paper›PMID 34445503›Full record

ArticleInternational journal of molecular sciences2021

Obesity Has a Systemic Effect on Immune Cells in Naïve and Cancer-Bearing Mice.

Silke Neumann, Katrin Campbell, Matthew J Woodall, Meghan Evans, Andrew N Clarkson, Sarah L Young

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Silke NeumannDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0003-3818-8259
Katrin CampbellDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0001-9491-3625
Matthew J WoodallDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0002-4034-4428
Meghan EvansDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.
Andrew N ClarksonBrain Health Research Centre and Brain Research New Zealand, Department of Anatomy, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0003-3804-3834
Sarah L YoungFaculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney 2006, Australia.
University of Otago · NZBrain Research New Zealand · NZThe University of Sydney · AU

Funding

Division of Health Sciences, University of Otago Dean's bequestMinistry of Business, Innovation and Employment N/A
6 · The paper itself

Abstract

Obesity is a major risk factor for developing cancer, with obesity-induced immune changes and inflammation in breast (BC) and colorectal cancer (CRC) providing a potential link between the two. This study investigates systemic effects of obesity on adaptive and innate immune cells in healthy and tumour-bearing mice. Immune cells from lean and obese mice were phenotyped prior to implantation of either BC (C57mg and EO771.LMB) or CRC (MC38) cells as tumour models. Tumour growth rate, tumour-infiltrating lymphocytes (TIL) and peripheral blood immune cell populations were compared between obese and lean mice. In vitro studies showed that naïve obese mice had higher levels of myeloid cells in the bone marrow and bone marrow-derived dendritic cells expressed lower levels of activation markers compared to cells from their lean counterparts. In the tumour setting, BC tumours grew faster in obese mice than in lean mice and lower numbers of TILs as well as higher frequency of exhausted T cells were observed. Data from peripheral blood showed lower levels of myeloid cells in tumour-bearing obese mice. This study highlights that systemic changes to the immune system are relevant for tumour burden and provides a potential mechanism behind the effects of obesity on cancer development and progression in patients.

Indexed as

Adaptive ImmunityAnimalsBreast NeoplasmsCell Line, TumorColorectal NeoplasmsFemaleHumansLymphocytes, Tumor-InfiltratingMaleMiceMyeloid CellsNeoplasm TransplantationObesityTumor Microenvironmentbreast cancercolorectal cancerinflammationmyeloid cellsobesitytumour-infiltrating lymphocytestumour microenvironment

Identifiers

PMID34445503
PMCPMC8395769
OpenAlexW3194853354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.