Evidence map›Paper›PMID 34445493›Full record

ArticleInternational journal of molecular sciences2021

Activation of Dendritic Cells in Tonsils Is Associated with CD8 T Cell Responses following Vaccination with Live Attenuated Classical Swine Fever Virus.

Ferran Soldevila, Jane C Edwards, Simon P Graham, Helen R Crooke, Dirk Werling, Falko Steinbach

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Strategies of Classical Swine Fever Immune Evasion.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ferran SoldevilaVirology Department, Animal and Plant Health Agency, Addlestone KT15 3NB, UK.ORCID 0000-0001-9472-623X
Jane C EdwardsVirology Department, Animal and Plant Health Agency, Addlestone KT15 3NB, UK.
Simon P GrahamVirology Department, Animal and Plant Health Agency, Addlestone KT15 3NB, UK.ORCID 0000-0003-4852-405X
Helen R CrookeVirology Department, Animal and Plant Health Agency, Addlestone KT15 3NB, UK.
Dirk WerlingDepartment of Pathobiology and Population Sciences, The Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire AL9 7TA, UK.ORCID 0000-0001-5411-4044
Falko SteinbachVirology Department, Animal and Plant Health Agency, Addlestone KT15 3NB, UK.
Animal and Plant Health Agency · GBRoyal Veterinary College · GBThe Pirbright Institute · GB

Funding

Department for Environment, Food and Rural Affairs, UK Government SE2207 & SE2210
6 · The paper itself

Abstract

Classical swine fever (CSF) is a highly contagious disease caused by the classical swine fever virus (CSFV). The live attenuated C-strain vaccine is highly efficacious, initiating protection within several days of delivery. The vaccine strain is detected in the tonsil early after inoculation, yet little is known of the role that tonsillar immune cells might play in initiating protection. Comparing the C-strain vaccine with the pathogenic CSFV Alfort-187 strain, changes in the myeloid cell compartment of the tonsil were observed. CSFV infection led to the emergence of an additional CD163

Indexed as

AnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenCD8-Positive T-LymphocytesClassical Swine FeverClassical Swine Fever VirusDendritic CellsInterferon-gammaLipopolysaccharide ReceptorsMyeloid CellsPalatine TonsilReceptors, Cell SurfaceSwineVaccines, AttenuatedViral LoadAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenInterferon-gammaLipopolysaccharide ReceptorsReceptors, Cell SurfaceVaccines, AttenuatedViral VaccinesCSFVdendritic cellsmacrophagesmyeloidpalatine tonsilpig

Identifiers

PMID34445493
PMCPMC8395915
OpenAlexW3196122089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.