Evidence map›Paper›PMID 34445488›Full record

ReviewInternational journal of molecular sciences2021

Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood.

Dae D Chung, Marisa R Pinson, Lokeshwar S Bhenderu, Michael S Lai, Rhea A Patel, Rajesh C Miranda

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  10. A head start: The relationship of placental factors to craniofacial and brain development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dae D ChungDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USA.ORCID 0000-0003-3844-7783
Marisa R PinsonDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USA.
Lokeshwar S BhenderuDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USA.ORCID 0000-0002-4944-7423
Michael S LaiDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USA.
Rhea A PatelDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USA.
Rajesh C MirandaDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USA.
Texas A&M Health Science Center · US

Funding

Prenatal microRNA neuro-therapeutics for fetal alcohol exposureR01AA024659 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MIRANDA, RAJESH C · 2016 to 2020
$1.8M
Gag-like Proteins in exosome-mediated Neural Development and Fetal Alcohol Spectrum DisordersF30AA027698 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI PINSON, MARISA · 2019 to 2023
$179k
Alcohol Effects on the Proteome and Transcriptome of Fetal Neural Stem Cell-Derived Extracellular Vesicles: Mechanism for Alcohol TeratogenesisF31AA028446 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CHUNG, DAE · 2020 to 2021
$69k
NIAAA NIH HHS F30AA027698NIAAA NIH HHS F31AA028446NIAAA NIH HHS R01AA024659
6 · The paper itself

Abstract

Prenatal alcohol exposure (PAE) can have immediate and long-lasting toxic and teratogenic effects on an individual's development and health. As a toxicant, alcohol can lead to a variety of physical and neurological anomalies in the fetus that can lead to behavioral and other impairments which may last a lifetime. Recent studies have focused on identifying mechanisms that mediate the immediate teratogenic effects of alcohol on fetal development and mechanisms that facilitate the persistent toxic effects of alcohol on health and predisposition to disease later in life. This review focuses on the contribution of epigenetic modifications and intercellular transporters like extracellular vesicles to the toxicity of PAE and to immediate and long-term consequences on an individual's health and risk of disease.

Indexed as

AdolescentAdolescent DevelopmentAdultEpigenesis, GeneticEthanolExtracellular VesiclesFemaleFetal DevelopmentGene Expression RegulationHumansPregnancyPrenatal Exposure Delayed EffectsTeratogenesisEthanolalcoholdevelopmental origin of health and diseaseearly childhood adversityepigenetic modificationextracellular vesiclesmiRNAprenatal alcohol exposure

Identifiers

PMID34445488
PMCPMC8395909
OpenAlexW3194635212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.