Structural Insights into Retinal Guanylate Cyclase Activator Proteins (GCAPs).

James B Ames

Open access · goldAbstract readReview

In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

0.7field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

cGMP Signaling in Photoreceptor Degeneration.International journal of molecular sciences · 2023
Review
CNG channel-related retinitis pigmentosa.Vision research · 2023
Article
Chemical shift assignments of retinal guanylyl cyclase activating protein 5 (GCAP5) with a mutation (R22A) that abolishes dimerization and enhances cyclase activation.Biomolecular NMR assignments · 2023
Article
Biology, Pathobiology and Gene Therapy of CNG Channel-Related Retinopathies.Biomedicines · 2023
Review
Retinal Cyclic Nucleotide-Gated Channel Regulation by Calmodulin.International journal of molecular sciences · 2022
Review
Zinc Modulation of Neuronal Calcium Sensor Proteins: Three Modes of Interaction with Different Structural Outcomes.Biomolecules · 2022
Article
Structural basis of retinal membrane guanylate cyclase regulation by GCAP1 and RD3.Frontiers in molecular neuroscience · 2022
Review
Changes in Cyclic Guanosine Monophosphate Channel of 661w Cells In vitro with Excessive Light Time.Journal of ophthalmic & vision research
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

James B AmesDepartment of Chemistry, University of California, Davis, CA 95616, USA.

University of California, Davis · US

Funding

MEMBRANE TARGETING CALCIUM SENSORS IN VISIONR01EY012347 · NEI · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI AMES, JAMES B · 1999 to 2023

$6.9M

NEI NIH HHS R01 EY012347NIH HHS R01 EY012347

6 · The paper itself

Abstract

Retinal guanylate cyclases (RetGCs) promote the Ca

Indexed as

AnimalsCalciumGuanylate Cyclase-Activating ProteinsHydrophobic and Hydrophilic InteractionsIronLight Signal TransductionModels, MolecularProtein ConformationProtein MultimerizationZebrafishZebrafish ProteinsCalciumGuanylate Cyclase-Activating Proteinsguca1a protein, zebrafishguca1e protein, zebrafishIronZebrafish ProteinscalciumGCAP1GCAP2GCAP5phototransductionretinal guanylate cyclase

Identifiers

PMID34445435

DOI10.3390/ijms22168731

PMCPMC8395740

OpenAlexW3194883311

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.