Evidence map›Paper›PMID 34445429›Full record

ReviewInternational journal of molecular sciences2021

Cyanobacteria, Cyanotoxins, and Neurodegenerative Diseases:

Paola Sini, Thi Bang Chau Dang, Milena Fais, Manuela Galioto, Bachisio Mario Padedda, Antonella Lugliè, Ciro Iaccarino, Claudia Crosio

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Paola SiniDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-7198-3564
Thi Bang Chau DangDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Milena FaisDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-4901-4521
Manuela GaliotoDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Bachisio Mario PadeddaLaboratory of Aquatic Ecology, Department of Architecture, Design and Urban Planning, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-0988-5613
Antonella LuglièLaboratory of Aquatic Ecology, Department of Architecture, Design and Urban Planning, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-6382-4208
Ciro IaccarinoDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0003-1619-7146
Claudia CrosioDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0003-2452-1145
University of Sassari · IT

Funding

Erasmus+ 2018-1-IT02-KA107-047494Fondazione di Sardegna Bando 2017- IaccarinoPON CCI2014IT16M2OP005UNISS Fondo di Ateneo per la Ricerca 2019-CrosioUNISS Fondo di Ateneo per la Ricerca 2019-Iaccarino
6 · The paper itself

Abstract

The prevalence of neurodegenerative disease (ND) is increasing, partly owing to extensions in lifespan, with a larger percentage of members living to an older age, but the ND aetiology and pathogenesis are not fully understood, and effective treatments are still lacking. Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis are generally thought to progress as a consequence of genetic susceptibility and environmental influences. Up to now, several environmental triggers have been associated with NDs, and recent studies suggest that some cyanotoxins, produced by cyanobacteria and acting through a variety of molecular mechanisms, are highly neurotoxic, although their roles in neuropathy and particularly in NDs are still controversial. In this review, we summarize the most relevant and recent evidence that points at cyanotoxins as environmental triggers in NDs development.

Indexed as

AnimalsBacterial ToxinsCyanobacteriaGenetic Predisposition to DiseaseHumansNeurodegenerative DiseasesBacterial ToxinsADALSAlzheimer DiseaseAmyotrophic Lateral SclerosiscyanobacteriacyanotoxinsL-BMAAneurodegenerative diseasesParkinson’s DiseasePD

Identifiers

PMID34445429
PMCPMC8395864
OpenAlexW3194778416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.