Evidence map›Paper›PMID 34445383›Full record

ReviewInternational journal of molecular sciences2021

Research Advances in Heterotrimeric G-Protein α Subunits and Uncanonical G-Protein Coupled Receptors in Plants.

Ying Liu, Xiaoyun Wang, Danhui Dong, Luqin Guo, Xiaonan Dong, Jing Leng, Bing Zhao, Yang-Dong Guo, Na Zhang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ying LiuDepartment of Vegetables, College of Horticulture, China Agricultural University, Beijing 100193, China.
Xiaoyun WangDepartment of Vegetables, College of Horticulture, China Agricultural University, Beijing 100193, China.
Danhui DongDepartment of Vegetables, College of Horticulture, China Agricultural University, Beijing 100193, China.
Luqin GuoDepartment of Vegetables, College of Horticulture, China Agricultural University, Beijing 100193, China.
Xiaonan DongDepartment of Vegetables, College of Horticulture, China Agricultural University, Beijing 100193, China.
Jing LengDepartment of Vegetables, College of Horticulture, China Agricultural University, Beijing 100193, China.
Bing ZhaoDepartment of Vegetables, College of Horticulture, China Agricultural University, Beijing 100193, China.
Yang-Dong GuoDepartment of Vegetables, College of Horticulture, China Agricultural University, Beijing 100193, China.
Na ZhangDepartment of Vegetables, College of Horticulture, China Agricultural University, Beijing 100193, China.
China Agricultural University · CN

Funding

Ministry of Science and Technology of the People's Republic of China 2019YFD1000300Ministry of Science and Technology of the People's Republic of China LJNY201812 and BAIC07Ministry of Science and Technology of the People's Republic of China NSFC32002053
6 · The paper itself

Abstract

As crucial signal transducers, G-proteins and G-protein-coupled receptors (GPCRs) have attracted increasing attention in the field of signal transduction. Research on G-proteins and GPCRs has mainly focused on animals, while research on plants is relatively rare. The mode of action of G-proteins is quite different from that in animals. The G-protein α (Gα) subunit is the most essential member of the G-protein signal cycle in animals and plants. The G-protein is activated when Gα releases GDP and binds to GTP, and the relationships with the GPCR and the downstream signal are also achieved by Gα coupling. It is important to study the role of Gα in the signaling pathway to explore the regulatory mechanism of G-proteins. The existence of a self-activated Gα in plants makes it unnecessary for the canonical GPCR to activate the G-protein by exchanging GDP with GTP. However, putative GPCRs have been found and proven to play important roles in G-protein signal transduction. The unique mode of action of G-proteins and the function of putative GPCRs in plants suggest that the same definition used in animal research cannot be used to study uncanonical GPCRs in plants. This review focuses on the different functions of the Gα and the mode of action between plants and animals as well as the functions of the uncanonical GPCR. This review employs a new perspective to define uncanonical GPCRs in plants and emphasizes the role of uncanonical GPCRs and Gα subunits in plant stress resistance and agricultural production.

Indexed as

Stress, PhysiologicalAnimalsGene Expression Regulation, PlantGTP-Binding Protein alpha SubunitsGuanosine DiphosphateGuanosine TriphosphateHumansPlant DevelopmentPlant ProteinsPlantsSignal TransductionGTP-Binding Protein alpha SubunitsGuanosine DiphosphateGuanosine TriphosphatePlant ProteinsGαself-activationsignal cycleuncanonical GPCR

Identifiers

PMID34445383
PMCPMC8395518
OpenAlexW3192014634

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.