Evidence map›Paper›PMID 34445367›Full record

ArticleInternational journal of molecular sciences2021

Hyperbilirubinemia Maintained by Chronic Supplementation of Unconjugated Bilirubin Improves the Clinical Course of Experimental Autoimmune Arthritis.

Tomas Sykora, Pavel Babal, Kristina Mikus-Kuracinova, Frantisek Drafi, Silvester Ponist, Monika Dvorakova, Pavol Janega, Katarina Bauerova

Open access · goldAbstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Research of Pathogenesis and Novel Therapeutics in Arthritis 3.0.International journal of molecular sciences · 2023
    Article
  4. Article
  5. The Underling Mechanisms Exploration ofDrug design, development and therapy · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tomas SykoraDepartment of Pathology, Faculty of Medicine, Comenius University in Bratislava, Spitalska 24, 81372 Bratislava, Slovakia.
Pavel BabalDepartment of Pathology, Faculty of Medicine, Comenius University in Bratislava, Spitalska 24, 81372 Bratislava, Slovakia.ORCID 0000-0001-8170-1850
Kristina Mikus-KuracinovaDepartment of Pathology, Faculty of Medicine, Comenius University in Bratislava, Spitalska 24, 81372 Bratislava, Slovakia.
Frantisek DrafiCentre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská Cesta 9, 84104 Bratislava, Slovakia.ORCID 0000-0001-9287-5514
Silvester PonistCentre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská Cesta 9, 84104 Bratislava, Slovakia.
Monika DvorakovaDepartment of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University in Bratislava, Spitalska 24, 81372 Bratislava, Slovakia.
Pavol JanegaDepartment of Pathology, Faculty of Medicine, Comenius University in Bratislava, Spitalska 24, 81372 Bratislava, Slovakia.ORCID 0000-0003-0036-7286
Katarina BauerovaCentre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská Cesta 9, 84104 Bratislava, Slovakia.
Comenius University Bratislava · SKSlovak Academy of Sciences · SK

Funding

Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR VEGA 2/0115/19Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky VEGA 2/0045/11Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky VEGA 2/0136/20
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic multisystem disease, therapy of which remains a challenge for basic research. The present work examined the effect of unconjugated bilirubin (UCB) administration in adjuvant-induced arthritis (AIA)-an experimental model, in which oxidative stress (OS), inflammation and inadequate immune response are often similar to RA. Male Lewis rats were randomized into groups: CO-control, AIA-untreated adjuvant-induced arthritis, AIA-BIL-adjuvant-induced arthritis administrated UCB, CO-BIL-control with administrated UCB. UCB was administered

Indexed as

AnimalsAnti-Inflammatory AgentsArthritis, ExperimentalBilirubinCeruloplasminC-Reactive ProteinFreund's AdjuvantInjections, IntraperitonealLipidsMaleMycobacteriumOxidative StressPeptide FragmentsRandom AllocationRatsRats, Inbred LewAnti-Inflammatory AgentsBilirubinCeruloplasminC-Reactive ProteinC-reactive protein (164-173)Freund's Adjuvantincomplete Freund's adjuvantLipidsPeptide Fragmentsadjuvant-induced arthritisbilirubinimmunomodulationinflammationwhite blood cells

Identifiers

PMID34445367
PMCPMC8395408
OpenAlexW3187077751

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.