Evidence map›Paper›PMID 34445366›Full record

ReviewInternational journal of molecular sciences2021

Current and Future Development in Lung Cancer Diagnosis.

Reem Nooreldeen, Horacio Bach

Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06473870 (Understanding Lung Cancer Related Risk Factors and Their Impact), which is not on this map. Cited by 470 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
470citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06473870 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Understanding Lung Cancer Related Risk Factors and Their Impact

Typeobservational_patient_registrySponsorBiobizkaia Health Research InstituteRan2024 to 2027Enrolled6,160ConditionsLung Cancer Screening
3 · Its place in the literature

Who cites it

470 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Review
  9. Vismodegib-loaded ufasomes inhaler for treatment of non-small cell lung cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
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  12. mCancer science · 2026
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410 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Reem NooreldeenDivision of Infectious Diseases, Faculty of Medicine, The University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Horacio BachDivision of Infectious Diseases, Faculty of Medicine, The University of British Columbia, Vancouver, BC V6H 3Z6, Canada.ORCID 0000-0002-7740-9299

Funding

Mitacs IT22349
6 · The paper itself

Abstract

Lung cancer is the leading cause of cancer-related deaths in North America and other developed countries. One of the reasons lung cancer is at the top of the list is that it is often not diagnosed until the cancer is at an advanced stage. Thus, the earliest diagnosis of lung cancer is crucial, especially in screening high-risk populations, such as smokers, exposure to fumes, oil fields, toxic occupational places, etc. Based on the current knowledge, it looks that there is an urgent need to identify novel biomarkers. The current diagnosis of lung cancer includes different types of imaging complemented with pathological assessment of biopsies, but these techniques can still not detect early lung cancer developments. In this review, we described the advantages and disadvantages of current methods used in diagnosing lung cancer, and we provide an analysis of the potential use of body fluids as carriers of biomarkers as predictors of cancer development and progression.

Indexed as

Biomarkers, TumorBiopsyDiagnostic ImagingDisease ProgressionEarly Detection of CancerHumansLung NeoplasmsOccupational DiseasesRisk FactorsSmokingBiomarkers, Tumorbiomarkersbody fluidsdiagnosisimaginglung cancerpredictors

Identifiers

PMID34445366
PMCPMC8395394

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.