Evidence map›Paper›PMID 34445364›Full record

ArticleInternational journal of molecular sciences2021

In Vivo Neocortical [K]o Modulation by Targeted Stimulation of Astrocytes.

Azin EbrahimAmini, Shanthini Mylvaganam, Paolo Bazzigaluppi, Mohamad Khazaei, Alexander Velumian, Bojana Stefanovic, Peter L Carlen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Azin EbrahimAminiKrembil Research Institute, Toronto, ON M5T 0S8, Canada.
Shanthini MylvaganamKrembil Research Institute, Toronto, ON M5T 0S8, Canada.
Paolo BazzigaluppiSunnybrook Health Sciences Center, Medical Biophysics, Toronto, ON M4N 3M5, Canada.
Mohamad KhazaeiKrembil Research Institute, Toronto, ON M5T 0S8, Canada.
Alexander VelumianDivision of Neurosurgery, University Health Network, Toronto, ON M5T 2S8, Canada.
Bojana StefanovicSunnybrook Health Sciences Center, Medical Biophysics, Toronto, ON M4N 3M5, Canada.
Peter L CarlenKrembil Research Institute, Toronto, ON M5T 0S8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A normally functioning nervous system requires normal extracellular potassium ion concentration ([K]o). Throughout the nervous system, several processes, including those of an astrocytic nature, are involved in [K]o regulation. In this study we investigated the effect of astrocytic photostimulation on [K]o. We hypothesized that in vivo photostimulation of eNpHR-expressing astrocytes leads to a decreased [K]o. Using optogenetic and electrophysiological techniques we showed that stimulation of eNpHR-expressing astrocytes resulted in a significantly decreased resting [K]o and evoked K responses. The amplitude of the concomitant spreading depolarization-like events also decreased. Our results imply that astrocytic membrane potential modification could be a potential tool for adjusting the [K]o.

Indexed as

AnimalsArchaeal ProteinsAstrocytesCell MembraneHalobacteriaceaeHalorhodopsinsMembrane PotentialsMiceNeocortexOptogeneticsPotassiumArchaeal ProteinsHalorhodopsinsPotassiumastrocyteastrocyte membrane potentialextracellular potassium concentrationhalorhodopsinhyperpolarization

Identifiers

PMID34445364
PMCPMC8395460

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.