Evidence map›Paper›PMID 34445350›Full record

ArticleInternational journal of molecular sciences2021

Preterm Intraventricular Hemorrhage-Induced Inflammatory Response in Human Choroid Plexus Epithelial Cells.

Zsolt Fejes, Marianna Pócsi, Jun Takai, Judit Erdei, Andrea Tóth, Enikő Balogh, Ágnes Rusznyák, Ferenc Fenyvesi, Andrea Nagy, János Kappelmayer and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mechanisms of hydrocephalus after intraventricular haemorrhage: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
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  8. Article
  9. Review
  10. Article
  11. Systemic Cytokines in Retinopathy of Prematurity.Journal of personalized medicine · 2023
    Review
  12. Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Zsolt FejesDepartment of Laboratory Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-1387-2970
Marianna PócsiDepartment of Laboratory Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Jun TakaiDepartment of Laboratory Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Judit ErdeiMTA-DE Lendület Vascular Pathophysiology Research Group, Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-1652-4506
Andrea TóthMTA-DE Lendület Vascular Pathophysiology Research Group, Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Enikő BaloghMTA-DE Lendület Vascular Pathophysiology Research Group, Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Ágnes RusznyákDepartment of Pharmaceutical Technologies, Faculty of Pharmacy, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-8837-7499
Ferenc FenyvesiDepartment of Pharmaceutical Technologies, Faculty of Pharmacy, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-2890-0783
Andrea NagyDepartment of Pediatrics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
János KappelmayerDepartment of Laboratory Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Viktória JeneyMTA-DE Lendület Vascular Pathophysiology Research Group, Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0003-4942-7091
Béla NagyDepartment of Laboratory Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-5700-3267
University of Debrecen · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following an intraventricular hemorrhage (IVH), red blood cell lysis and hemoglobin (Hb) oxidation with the release of heme can cause sterile neuroinflammation. In this study, we measured Hb derivates and cellular adhesion molecules ICAM-1 and VCAM-1 with cell-free miRNAs in cerebrospinal fluid (CSF) samples obtained from Grade-III and Grade-IV preterm IVH infants (IVH-III and IVH-IV, respectively) at multiple time points between days 0-60 after the onset of IVH. Furthermore, human choroid plexus epithelial cells (HCPEpiCs) were incubated with IVH and non-IVH CSF (10

Indexed as

Case-Control StudiesCerebral HemorrhageChoroid PlexusCohort StudiesC-Reactive ProteinCytokinesEpithelial CellsFemaleHemeHemoglobinsHumansHungaryInfant, NewbornInfant, PrematureIntercellular Adhesion Molecule-1MaleC-Reactive ProteinCytokinesHemeHemoglobinsICAM1 protein, humanIntercellular Adhesion Molecule-1Vascular Cell Adhesion Molecule-1cerebrospinal fluidchoroid plexus epithelial cellhemeinflammationintraventricular hemorrhagemicroRNAoxidized hemoglobin

Identifiers

PMID34445350
PMCPMC8395401
OpenAlexW3191854364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.