Evidence map›Paper›PMID 34445342›Full record

ArticleInternational journal of molecular sciences2021

Evaluation of Class IIa Histone Deacetylases Expression and In Vivo Epigenetic Imaging in a Transgenic Mouse Model of Alzheimer's Disease.

Yi-An Chen, Cheng-Hsiu Lu, Chien-Chih Ke, Sain-Jhih Chiu, Chi-Wei Chang, Bang-Hung Yang, Juri G Gelovani, Ren-Shyan Liu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

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  5. Epigenetics in Neurodegenerative Diseases.Sub-cellular biochemistry · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Yi-An ChenInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.ORCID 0000-0002-8002-6256
Cheng-Hsiu LuMolecular and Genetic Imaging Core/Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei 112, Taiwan.ORCID 0000-0001-8428-1417
Chien-Chih KeDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Sain-Jhih ChiuMolecular and Genetic Imaging Core/Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei 112, Taiwan.
Chi-Wei ChangNational PET and Cyclotron Center (NPCC), Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Bang-Hung YangNational PET and Cyclotron Center (NPCC), Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Juri G GelovaniOffice of the Provost, United Arab Emirates University, Al Ain P.O. Box 1551, United Arab Emirates.
Ren-Shyan LiuInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
National Yang Ming Chiao Tung University · TWElectronics Testing Center · TWKaohsiung Medical University · TWTaipei Veterans General Hospital · TWUnited Arab Emirates University · AE

Funding

Kaohsiung Medical University KMU-M11010Kaohsiung Medical University KMUQ109004Ministry of Science and Technology MOST 108-2314-B010-017Ministry of Science and Technology MOST108-2314-B-037-015
6 · The paper itself

Abstract

Epigenetic regulation by histone deacetylase (HDAC) is associated with synaptic plasticity and memory formation, and its aberrant expression has been linked to cognitive disorders, including Alzheimer's disease (AD). This study aimed to investigate the role of class IIa HDAC expression in AD and monitor it in vivo using a novel radiotracer, 6-(tri-fluoroacetamido)-1-hexanoicanilide ([

Indexed as

Alzheimer DiseaseAnilidesAnimalsBrainDisease Models, AnimalEpigenesis, GeneticFluorine RadioisotopesFluoroacetatesGene Expression Regulation, EnzymologicHistone Deacetylase InhibitorsHistone DeacetylasesHumansMiceMice, 129 StrainMice, Inbred C57BLMice, Transgenic6-(trifluoroacetamido)-1-hexanoicanilideAnilidesFluorine-18Fluorine RadioisotopesFluoroacetatesHistone Deacetylase InhibitorsHistone DeacetylasesAlzheimer’s diseaseamyloid-βepigenetic regulationHDAC inhibitorhistone deacetylasePET imaging

Identifiers

PMID34445342
PMCPMC8395513
OpenAlexW3188403568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.