Evidence map›Paper›PMID 34445340›Full record

ArticleInternational journal of molecular sciences2021

Signaling Role of Mitochondrial Enzymes and Ultrastructure in the Formation of Molecular Mechanisms of Adaptation to Hypoxia.

Ludmila Lukyanova, Elita Germanova, Natalya Khmil, Lybov Pavlik, Irina Mikheeva, Maria Shigaeva, Galina Mironova

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ludmila LukyanovaInstitute of General Pathology and Pathophysiology, Baltijskaya Str. 8., 125315 Moscow, Russia.ORCID 0000-0003-1259-9930
Elita GermanovaInstitute of General Pathology and Pathophysiology, Baltijskaya Str. 8., 125315 Moscow, Russia.
Natalya KhmilInstitute of Theoretical and Experimental Biophysics RAS, Pushchino, 142290 Moscow, Russia.
Lybov PavlikInstitute of Theoretical and Experimental Biophysics RAS, Pushchino, 142290 Moscow, Russia.
Irina MikheevaInstitute of Theoretical and Experimental Biophysics RAS, Pushchino, 142290 Moscow, Russia.
Maria ShigaevaInstitute of Theoretical and Experimental Biophysics RAS, Pushchino, 142290 Moscow, Russia.
Galina MironovaInstitute of Theoretical and Experimental Biophysics RAS, Pushchino, 142290 Moscow, Russia.

Funding

Russian Foundation for Basic Research 20-015-00029-а
6 · The paper itself

Abstract

This study was the first comprehensive investigation of the dependence of mitochondrial enzyme response (catalytic subunits of mitochondrial complexes (MC) I-V, including NDUFV2, SDHA, Cyt b, COX1 and ATP5A) and mitochondrial ultrastructure in the rat cerebral cortex (CC) on the severity and duration of in vivo hypoxic exposures. The role of individual animal's resistance to hypoxia was also studied. The respiratory chain (RC) was shown to respond to changes in environmental [O

Indexed as

Adaptation, PhysiologicalAnimalsAnimals, Outbred StrainsCell RespirationCerebral CortexElectron TransportHypoxiaMitochondriaMitochondrial ProteinsProtein ConformationRatsMitochondrial Proteinsadaptation to hypoxiacatalytic subunits of mitochondrial complexes (MC- I-V)mitochondrial dynamicsmitochondrial enzymes

Identifiers

PMID34445340
PMCPMC8395493

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.