Evidence map›Paper›PMID 34445312›Full record

ArticleInternational journal of molecular sciences2021

A Time-Course Study of the Expression Level of Synaptic Plasticity-Associated Genes in Un-Lesioned Spinal Cord and Brain Areas in a Rat Model of Spinal Cord Injury: A Bioinformatic Approach.

Vito Antonio Baldassarro, Marco Sanna, Andrea Bighinati, Michele Sannia, Marco Gusciglio, Luciana Giardino, Luca Lorenzini, Laura Calzà

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Vito Antonio BaldassarroDepartment of Veterinary Medical Science, University of Bologna, Via Tolara di Sopra, 50, 40064 Ozzano Emilia, Italy.ORCID 0000-0003-1020-4261
Marco SannaInterdepartmental Center for Industrial Research in Life Sciences and Technologies, University of Bologna, Via Tolara di Sopra, 41/E, 40064 Ozzano Emilia, Italy.ORCID 0000-0001-5709-5782
Andrea BighinatiDepartment of Veterinary Medical Science, University of Bologna, Via Tolara di Sopra, 50, 40064 Ozzano Emilia, Italy.ORCID 0000-0002-7584-1934
Michele SanniaInterdepartmental Center for Industrial Research in Life Sciences and Technologies, University of Bologna, Via Tolara di Sopra, 41/E, 40064 Ozzano Emilia, Italy.
Marco GusciglioIRET Foundation, Via Tolara di Sopra, 41/E, 40064 Ozzano Emilia, Italy.
Luciana GiardinoDepartment of Veterinary Medical Science, University of Bologna, Via Tolara di Sopra, 50, 40064 Ozzano Emilia, Italy.
Luca LorenziniDepartment of Veterinary Medical Science, University of Bologna, Via Tolara di Sopra, 50, 40064 Ozzano Emilia, Italy.ORCID 0000-0002-5257-0131
Laura CalzàInterdepartmental Center for Industrial Research in Life Sciences and Technologies, University of Bologna, Via Tolara di Sopra, 41/E, 40064 Ozzano Emilia, Italy.
University of Bologna · ITFondazione IRET ONLUS · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca Cluster Tecnologici Nazionali, project IRMIRegione Emilia-Romagna POR-FESR 2019-21 Mat2Rep
6 · The paper itself

Abstract

"Neuroplasticity" is often evoked to explain adaptation and compensation after acute lesions of the Central Nervous System (CNS). In this study, we investigated the modification of 80 genes involved in synaptic plasticity at different times (24 h, 8 and 45 days) from the traumatic spinal cord injury (SCI), adopting a bioinformatic analysis. mRNA expression levels were analyzed in the motor cortex, basal ganglia, cerebellum and in the spinal segments rostral and caudal to the lesion. The main results are: (i) a different gene expression regulation is observed in the Spinal Cord (SC) segments rostral and caudal to the lesion; (ii) long lasting changes in the SC includes the extracellular matrix (ECM) enzymes

Indexed as

TranscriptomeAnimalsBrainFemaleMitogen-Activated Protein Kinase 1Nerve Growth FactorsNeuronal PlasticityNeurotransmitter AgentsRatsRats, Sprague-DawleyReelin ProteinSpinal CordSpinal Cord InjuriesTissue Inhibitor of Metalloproteinase-1Transcription FactorsMapk1 protein, ratMitogen-Activated Protein Kinase 1Nerve Growth FactorsNeurotransmitter AgentsReelin ProteinReln protein, ratTIMP1 protein, ratTissue Inhibitor of Metalloproteinase-1Transcription Factorsbioinformatic analysisratspinal cord injurytranscriptomic

Identifiers

PMID34445312
PMCPMC8395345
OpenAlexW3189273687

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.