Evidence map›Paper›PMID 34445301›Full record

ArticleInternational journal of molecular sciences2021

Effect of Neprilysin Inhibition for Ischemic Mitral Regurgitation after Myocardial Injury.

Sahmin Lee, Hyo-Sook Hwang, Naaleum Song, Geun-Hyung Kang, Kyoung-Hee Choi, Eunhye Ji, Jong-Min Song, Duk-Hyun Kang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sahmin LeeDivision of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID 0000-0003-2250-7948
Hyo-Sook HwangDivision of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Naaleum SongDivision of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID 0000-0002-2278-7698
Geun-Hyung KangDivision of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Kyoung-Hee ChoiDivision of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Eunhye JiDivision of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Jong-Min SongDivision of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Duk-Hyun KangDivision of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Ulsan College · KR

Funding

Asan Institute for Life Sciences, Asan Medical Center 2019IP-0823, 2020IP-0086Korea Health Industry Development Institute HR20C0026National Research Foundation of Korea 2019R1I1A2A01060702
6 · The paper itself

Abstract

Angiotensin receptor neprilysin inhibitor (ARNI) treatment reduces functional mitral regurgitation (MR) to a greater extent than angiotensin receptor blocker (ARB) treatment alone, but the mechanism is unclear. We evaluated the mechanisms of how ARNI has an effect on functional MR. After inducing functional MR by left circumflex coronary artery occlusion, male Sprague Dawley rats (

Indexed as

AminobutyratesAngiotensin Receptor AntagonistsAnimalsBiphenyl CompoundsCells, CulturedDrug CombinationsEndothelial CellsHeart FailureHumansMaleMitral ValveMitral Valve InsufficiencyMyocardial InfarctionMyocardial Reperfusion InjuryNeprilysinRatsAminobutyratesAngiotensin Receptor AntagonistsBiphenyl CompoundsDrug CombinationsNeprilysinsacubitril and valsartan sodium hydrate drug combinationValsartanangiotensin receptor antagonistsheart failureheart ventriclesmitral valve insufficiencyneprilysin

Identifiers

PMID34445301
PMCPMC8395283
OpenAlexW3190126021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.