Evidence map›Paper›PMID 34445270›Full record

ArticleInternational journal of molecular sciences2021

NAD(H) Regulates the Permeability Transition Pore in Mitochondria through an External Site.

Ekaterina Kharechkina, Anna Nikiforova, Alexey Kruglov

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. [Therapeutic potential of NADH: in neurodegenerative diseases characterizde by mitochondrial dysfunction].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  3. Article
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ekaterina KharechkinaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia.
Anna NikiforovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia.
Alexey KruglovInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia.ORCID 0000-0001-9215-7387
Institute of Theoretical and Experimental Biophysics · RU

Funding

Ministry of Education and Science of the Russian Federation State assignment 075-00381-21-00
6 · The paper itself

Abstract

The opening of the permeability transition pore (mPTP) in mitochondria initiates cell death in numerous diseases. The regulation of mPTP by NAD(H) in the mitochondrial matrix is well established; however, the role of extramitochondrial (cytosolic) NAD(H) is still unclear. We studied the effect of added NADH and NAD

Indexed as

AnimalsCalciumFluoresceinsHepatocytesMaleMitochondria, HeartMitochondria, LiverMitochondrial Permeability Transition PoreNADRatsRats, WistarCalciumFluoresceinsfluorexonMitochondrial Permeability Transition PoreNADcalcium retention capacitycytosolicexternal regulatory siteNAD+NADHpermeability transition porepore closure

Identifiers

PMID34445270
PMCPMC8395297
OpenAlexW3191325286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.