Evidence map›Paper›PMID 34445265›Full record

ArticleInternational journal of molecular sciences2021

Suitability of the In Vitro Cytokinesis-Block Micronucleus Test for Genotoxicity Assessment of TiO

Natalia Fernández-Bertólez, Fátima Brandão, Carla Costa, Eduardo Pásaro, João Paulo Teixeira, Blanca Laffon, Vanessa Valdiglesias

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cytotoxicity and Genotoxicity of Nanomaterials.Nanomaterials (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Natalia Fernández-BertólezUniversidade da Coruña, Grupo DICOMOSA, Centro de Investigaciones Científicas Avanzadas (CICA), Departamento de Psicología, Facultad de Ciencias de la Educación, Campus Elviña s/n, 15071 A Coruña, Spain.
Fátima BrandãoEPIUnit-Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, N° 135, 4050-600 Porto, Portugal.ORCID 0000-0002-2933-8561
Carla CostaEPIUnit-Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, N° 135, 4050-600 Porto, Portugal.
Eduardo PásaroUniversidade da Coruña, Grupo DICOMOSA, Centro de Investigaciones Científicas Avanzadas (CICA), Departamento de Psicología, Facultad de Ciencias de la Educación, Campus Elviña s/n, 15071 A Coruña, Spain.ORCID 0000-0003-0650-8852
João Paulo TeixeiraEPIUnit-Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, N° 135, 4050-600 Porto, Portugal.ORCID 0000-0001-8693-5250
Blanca LaffonUniversidade da Coruña, Grupo DICOMOSA, Centro de Investigaciones Científicas Avanzadas (CICA), Departamento de Psicología, Facultad de Ciencias de la Educación, Campus Elviña s/n, 15071 A Coruña, Spain.ORCID 0000-0001-7649-2599
Vanessa ValdiglesiasInstituto de Investigación Biomédica de A Coruña (INIBIC), AE CICA-INIBIC. Oza, 15071 A Coruña, Spain.ORCID 0000-0002-5572-1089
Universidade da Coruña · ESUniversidade do Porto · PT

Funding

COMPETE 2020, Portugal 2020 and European Union, through FEDER PTDC/SAU-PUB/29651/2017Fundação para a Ciência e a Tecnologia SFRH/BD/101060/2014Ministerio de Educación, Cultura y Deporte BEAGAL18/00142Operational Program for Competitiveness and Internationalisation through European Regional Development Funds (FEDER/FNR) and through national funds by the Portuguese Foundation for Science and Technology PTDC/MED-TOX/31162/2017Xunta de Galicia ED431B 2019/02
6 · The paper itself

Abstract

Standard toxicity tests might not be fully adequate for evaluating nanomaterials since their unique features are also responsible for unexpected interactions. The in vitro cytokinesis-block micronucleus (CBMN) test is recommended for genotoxicity testing, but cytochalasin-B (Cyt-B) may interfere with nanoparticles (NP), leading to inaccurate results. Our objective was to determine whether Cyt-B could interfere with MN induction by TiO

Indexed as

Micronuclei, Chromosome-DefectiveCell Line, TumorCytochalasin BCytokinesisDose-Response Relationship, DrugHumansNanoparticlesTitaniumCytochalasin BTitaniumtitanium dioxidecytochalasin-Bcytokinesis-block micronucleus testflow cytometry micronucleus testnanomaterialsSH-SY5Y cellsTiO2 nanoparticlesuptake

Identifiers

PMID34445265
PMCPMC8395234
OpenAlexW3189325685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.