Evidence map›Paper›PMID 34445239›Full record

ArticleInternational journal of molecular sciences2021

The Antimalarial Mefloquine Shows Activity against

Giulia Degiacomi, Laurent Roberto Chiarelli, Deborah Recchia, Elena Petricci, Beatrice Gianibbi, Ersilia Vita Fiscarelli, Lanfranco Fattorini, Fabrizio Manetti, Maria Rosalia Pasca

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Giulia DegiacomiDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.
Laurent Roberto ChiarelliDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0003-0348-9764
Deborah RecchiaDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-2735-5165
Elena PetricciDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-9685-6342
Beatrice GianibbiDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-4946-8398
Ersilia Vita FiscarelliCystic Fibrosis Diagnostics, Microbiology and Immunology Diagnostics, Bambino Gesù Children's Hospital IRCCS, 00165 Rome, Italy.ORCID 0000-0003-4156-1835
Lanfranco FattoriniDipartimento di Malattie Infettive, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-1673-1804
Fabrizio ManettiDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0002-9598-2339
Maria Rosalia PascaDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-8906-4937
University of Pavia · ITUniversity of Siena · ITBambino Gesù Children's Hospital · ITIstituto Superiore di Sanità · IT

Funding

Fondazione per la Ricerca sulla Fibrosi Cistica FFC#14/2020Italian Ministry of Education, University and Research (MIUR): Dipartimenti di Eccellenza Pro-gram (2018-2022) Dept. of Biology and Biotechnology "L. Spallanzani", University of PaviaItalian Ministry of Education, University and Research (MIUR): Dipartimenti di Eccellenza Pro-gram (2018-2022) Dept. of Biotechnology Chemistry and Pharmacy, University of Siena
6 · The paper itself

Abstract

Some nontuberculous mycobacteria (NTM) are considered opportunistic pathogens. Nevertheless, NTM infections are increasing worldwide, becoming a major public health threat. Furthermore, there is no current specific drugs to treat these infections, and the recommended regimens generally lack efficacy, emphasizing the need for novel antibacterial compounds. In this paper, we focused on the essential mycolic acids transporter MmpL3, which is a well-characterized target of several antimycobacterial agents, to identify new compounds active against

Indexed as

Anti-Bacterial AgentsAntimalarialsMefloquineMycobacterium abscessusMycolic AcidsAnti-Bacterial AgentsAntimalarialsMefloquineMycolic Acidsdrug repurposingmefloquineMmpL3Mycobacterium abscessuspharmacophore model

Identifiers

PMID34445239
PMCPMC8395226
OpenAlexW3188958068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.