Evidence map›Paper›PMID 34445187›Full record

ArticleInternational journal of molecular sciences2021

Decreased Levels of Microfibril-Associated Glycoprotein (MAGP)-1 in Patients with Colon Cancer and Obesity Are Associated with Changes in Extracellular Matrix Remodelling.

Iranzu Gómez de Segura, Patricia Ahechu, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Sara Becerril, Xabier Unamuno, Amaia Mentxaka, Jorge Baixauli, Víctor Valentí and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Biomedicines · 2026
    Article
  3. Review
  4. Article
  5. Immunosuppressive MFAP2Cellular oncology (Dordrecht, Netherlands) · 2024
    Article
  6. MFAP2 promotes HSCs activation through FBN1/TGF-β/Smad3 pathway.Journal of cellular and molecular medicine · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Iranzu Gómez de SeguraMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-9844-4501
Patricia AhechuDepartment of Surgery, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Javier Gómez-AmbrosiMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0001-5601-1604
Amaia RodríguezMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-2180-461X
Beatriz RamírezMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Sara BecerrilMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Xabier UnamunoMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-4260-1325
Amaia MentxakaMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Jorge BaixauliDepartment of Surgery, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Víctor ValentíDepartment of Surgery, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Rafael MoncadaCIBEROBN, Instituto de Salud Carlos III, 31008 Pamplona, Spain.ORCID 0000-0002-5871-3156
Camilo SilvaCIBEROBN, Instituto de Salud Carlos III, 31008 Pamplona, Spain.
Gema FrühbeckMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-8305-7154
Victoria CatalánMetabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-7513-7509
Instituto de Salud Carlos III · ESClinica Universidad de Navarra · ES

Funding

Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición 2021Fundación Científica Asociación Española Contra el Cáncer 2019Instituto de Salud Carlos III PI19/00785Instituto de Salud Carlos III PI20/00080Instituto de Salud Carlos III PI20/00927
6 · The paper itself

Abstract

objectiveThe protein microfibril-associated glycoprotein (MAGP)-1 constitutes a crucial extracellular matrix protein. We aimed to determine its impact on visceral adipose tissue (VAT) remodelling during obesity-associated colon cancer (CC).

methodsSamples obtained from 79 subjects (29 normoponderal (NP) (17 with CC) and 50 patients with obesity (OB) (19 with CC)) were used in the study. Circulating concentrations of MAGP-1 and its gene expression levels (

resultsObesity (

Indexed as

AgedCarcinogenesisColonic NeoplasmsExtracellular MatrixFemaleGene Expression Regulation, NeoplasticHT29 CellsHumansMaleMiddle AgedObesityRNA Splicing Factorsmicrofibrillar proteinRNA Splicing Factorsadipose tissuecolon cancerextracellular matrix remodellinginflammationMAGP-1obesityTGF-β

Identifiers

PMID34445187
PMCPMC8395192
OpenAlexW3192409917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.