Evidence map›Paper›PMID 34445183›Full record

ArticleInternational journal of molecular sciences2021

YY1 Silencing Induces 5-Fluorouracil-Resistance and

Silvia Vivarelli, Luca Falzone, Saverio Candido, Benjamin Bonavida, Massimo Libra

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. The YYR (YY1- RKIP) Regulatory Axis in the pathogenesis of Cancer and Immune Evasion.Journal of experimental & clinical cancer research : CR · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Silvia VivarelliDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-9363-6523
Luca FalzoneEpidemiology and Biostatistics Unit, IRCCS Istituto Nazionale Tumori "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0001-7349-6826
Saverio CandidoDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Benjamin BonavidaDepartment of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Massimo LibraDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-7232-7737
University of Catania · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is characterized by genetic heterogeneity and is often diagnosed at an advanced stage. Therefore, there is a need to identify novel predictive markers. Yin Yang 1 (YY1) is a transcription factor playing a dual role in cancer. The present study aimed to investigate whether YY1 expression levels influence CRC cell response to therapy and to identify the transcriptional targets involved. The diagnostic and prognostic values of YY1 and the identified factor(s) in CRC patients were also explored. Silencing of

Indexed as

Drug Resistance, NeoplasmAntimetabolites, AntineoplasticCell Line, TumorColorectal NeoplasmsDown-RegulationFluorouracilGene Expression Regulation, NeoplasticHumansProto-Oncogene Proteins c-bcl-2YY1 Transcription FactorAntimetabolites, AntineoplasticBCL2L15 protein, humanFluorouracilProto-Oncogene Proteins c-bcl-2YY1 protein, humanYY1 Transcription FactorBCL2L15/Bfkbiomarkerscolorectal cancertumor-suppressorYin Yang 1

Identifiers

PMID34445183
PMCPMC8395225
OpenAlexW3189862696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.