Evidence map›Paper›PMID 34445084›Full record

ReviewInternational journal of molecular sciences2021

Immunity in Atherosclerosis: Focusing on T and B Cells.

Anastasia V Poznyak, Evgeny E Bezsonov, Tatyana V Popkova, Antonina V Starodubova, Alexander N Orekhov

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  6. Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
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  15. Article
  16. Article
  17. Inflammatory Cells in Atherosclerosis.Antioxidants (Basel, Switzerland) · 2022
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Anastasia V PoznyakInstitute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, Russia.ORCID 0000-0002-1516-1320
Evgeny E BezsonovLaboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia.ORCID 0000-0002-9382-8338
Tatyana V PopkovaV.A. Nasonova Institute of Rheumatology, 34A Kashirskoye Shosse, 115522 Moscow, Russia.
Antonina V StarodubovaFederal Research Centre for Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Passage, 109240 Moscow, Russia.
Alexander N OrekhovInstitute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, Russia.ORCID 0000-0002-3318-4681
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RUAssociation of Rheumatologists of Russia · RUFederal Research Centre of Nutrition and Biotechnology · RUInstitute for Atherosclerosis Research · RU

Funding

Russian Science Foundation 18-15-00254
6 · The paper itself

Abstract

Atherosclerosis is the major cause of the development of cardiovascular disease, which, in turn, is one of the leading causes of mortality worldwide. From the point of view of pathogenesis, atherosclerosis is an extremely complex disease. A huge variety of processes, such as violation of mitophagy, oxidative stress, damage to the endothelium, and others, are involved in atherogenesis; however, the main components of atherogenesis are considered to be inflammation and alterations of lipid metabolism. In this review, we want to focus on inflammation, and more specifically on the cellular elements of adaptive immunity, T and B cells. It is known that various T cells are widely represented directly in atherosclerotic plaques, while B cells can be found, for example, in the adventitia layer. Of course, such widespread and well-studied cells have attracted attention as potential therapeutic targets for the treatment of atherosclerosis. Various approaches have been developed and tested for their efficacy.

Indexed as

ImmunityAdaptive ImmunityAnimalsAtherosclerosisB-LymphocytesHumansImmunity, CellularInflammationT-LymphocytesatherosclerosisB cellsCVDimmunityT cells

Identifiers

PMID34445084
PMCPMC8395064
OpenAlexW3189286474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.