Evidence map›Paper›PMID 34445071›Full record

ArticleInternational journal of molecular sciences2021

Ageing Causes Ultrastructural Modification to Calcium Release Units and Mitochondria in Cardiomyocytes.

Alessia Di Fonso, Laura Pietrangelo, Laura D'Onofrio, Antonio Michelucci, Simona Boncompagni, Feliciano Protasi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The Role of Oxidative Stress in the Aging Heart.Antioxidants (Basel, Switzerland) · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alessia Di FonsoCAST, Center for Advanced Studies and Technology, University G. d'Annunzio (Ud'A) of Chieti-Pescara, 66100 Chieti, Italy.
Laura PietrangeloCAST, Center for Advanced Studies and Technology, University G. d'Annunzio (Ud'A) of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-1197-7813
Laura D'OnofrioIZSAM, Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale of Teramo, 64100 Teramo, Italy.
Antonio MichelucciCAST, Center for Advanced Studies and Technology, University G. d'Annunzio (Ud'A) of Chieti-Pescara, 66100 Chieti, Italy.
Simona BoncompagniCAST, Center for Advanced Studies and Technology, University G. d'Annunzio (Ud'A) of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0001-5308-5069
Feliciano ProtasiCAST, Center for Advanced Studies and Technology, University G. d'Annunzio (Ud'A) of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-0213-7591
University of Chieti-Pescara · ITIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale · IT

Funding

Italian Ministry of University and Research PRIN n. 2015ZZR4W3Italian Telethon ONLUS GGP19231National Institutes of Health USA subcontract of AR059646-06
6 · The paper itself

Abstract

Ageing is associated with an increase in the incidence of heart failure, even if the existence of a real age-related cardiomyopathy remains controversial. Effective contraction and relaxation of cardiomyocytes depend on efficient production of ATP (handled by mitochondria) and on proper Ca

Indexed as

AgingAnimalsCalciumCellular SenescenceExcitation Contraction CouplingMaleMiceMice, Inbred C57BLMitochondria, HeartMyocytes, CardiacCalciumexcitation contraction (EC) couplingheart failure (HF)ryanodine receptor (RYR)sarcoplasmic reticulum (SR)

Identifiers

PMID34445071
PMCPMC8395047
OpenAlexW2066275168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.