Evidence map›Paper›PMID 34445066›Full record

ArticleInternational journal of molecular sciences2021

TRPM2 Oxidation Activates Two Distinct Potassium Channels in Melanoma Cells through Intracellular Calcium Increase.

Loretta Ferrera, Raffaella Barbieri, Cristiana Picco, Paolo Zuccolini, Alessia Remigante, Sara Bertelli, Maria Rita Fumagalli, Giovanni Zifarelli, Caterina A M La Porta, Paola Gavazzo and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Metal Ions Within the Neuro-Immune-Tumor Axis.Journal of immunology research · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. TRPM2 Channels: A Potential Therapeutic Target in Melanoma?International journal of molecular sciences · 2023
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. GABACells · 2022
    Article
  17. IKCell death & disease · 2022
    Article
  18. Review
  19. Antioxidant Activity of Quercetin in a HInternational journal of molecular sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Loretta FerreraBiophysics Institute, National Research Council, 16149 Genova, Italy.ORCID 0000-0003-0528-1158
Raffaella BarbieriBiophysics Institute, National Research Council, 16149 Genova, Italy.ORCID 0000-0001-8254-9758
Cristiana PiccoBiophysics Institute, National Research Council, 16149 Genova, Italy.ORCID 0000-0002-6512-1802
Paolo ZuccoliniBiophysics Institute, National Research Council, 16149 Genova, Italy.
Alessia RemiganteBiophysics Institute, National Research Council, 16149 Genova, Italy.ORCID 0000-0001-9934-293X
Sara BertelliBiophysics Institute, National Research Council, 16149 Genova, Italy.
Maria Rita FumagalliBiophysics Institute, National Research Council, 16149 Genova, Italy.
Giovanni ZifarelliBiophysics Institute, National Research Council, 16149 Genova, Italy.
Caterina A M La PortaBiophysics Institute, National Research Council, 16149 Genova, Italy.ORCID 0000-0002-3010-8966
Paola GavazzoBiophysics Institute, National Research Council, 16149 Genova, Italy.
Michael PuschBiophysics Institute, National Research Council, 16149 Genova, Italy.ORCID 0000-0002-8644-8847
Instituto di Biofisica · ESUniversity of Milan · ITIstituto Giannina Gaslini · ITUniversity of Messina · IT

Funding

Associazione Italiana per la Ricerca sul Cancro IG 21558Italian Ministry of Research PRIN 20174TB8KW
6 · The paper itself

Abstract

Tumor microenvironments are often characterized by an increase in oxidative stress levels. We studied the response to oxidative stimulation in human primary (IGR39) or metastatic (IGR37) cell lines obtained from the same patient, performing patch-clamp recordings, intracellular calcium ([Ca

Indexed as

CalciumCell Line, TumorHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMelanomaOxidation-ReductionTRPM Cation ChannelsCalciumIntermediate-Conductance Calcium-Activated Potassium ChannelsKCNMA1 protein, humanKCNN4 protein, humanLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsTRPM2 protein, humanTRPM Cation Channelsintracellular calciummelanomaoxidative stresspotassium channelsTRP channels

Identifiers

PMID34445066
PMCPMC8393965
OpenAlexW3191342351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.