Evidence map›Paper›PMID 34445060›Full record

ArticleNutrients2021

Genetically Predicted Milk Intake and Risk of Neurodegenerative Diseases.

Zhizhong Zhang, Mengmeng Wang, Shuai Yuan, Susanna C Larsson, Xinfeng Liu

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Zhizhong ZhangDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Mengmeng WangDepartment of Neurology, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou 213004, China.
Shuai YuanUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0001-5055-5627
Susanna C LarssonUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID 0000-0003-0118-0341
Xinfeng LiuDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
Karolinska Institutet · SENanjing General Hospital of Nanjing Military Command · CNSoochow University · CN

Funding

National Natural Science Foundation of China 81771285National Natural Science Foundation of China U20A20357
6 · The paper itself

Abstract

Milk intake has been associated with risk of neurodegenerative diseases in observational studies. Nevertheless, whether the association is causal remains unknown. We adopted Mendelian randomization design to evaluate the potential causal association between milk intake and common neurodegenerative diseases, including multiple sclerosis (MS), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD). Genetic associations for neurodegenerative diseases were obtained from the International Multiple Sclerosis Genetics Consortium (

Indexed as

Gene-Environment InteractionMilkPolymorphism, Single NucleotideAlzheimer DiseaseAmyotrophic Lateral SclerosisAnimalsCase-Control StudiesDatabases, GeneticGenetic Association StudiesGenetic Predisposition to DiseaseHumansLactaseMendelian Randomization AnalysisMultiple SclerosisNeurodegenerative DiseasesParkinson DiseaseLactasecausal effectmilkneurodegenerative disease

Identifiers

PMID34445060
PMCPMC8398304
OpenAlexW3196091135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.