Evidence map›Paper›PMID 34445027›Full record

Observational studyNutrients2021

Protein Enrichment of Donor Breast Milk and Impact on Growth in Very Low Birth Weight Infants.

Ting Ting Fu, Heather C Kaplan, Trayce Fields, Alonzo T Folger, Katelyn Gordon, Brenda B Poindexter

Abstract readComparative StudyObservational Study
In one paragraph

Observational study in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Osmolality of fortified human milk with contemporary human milk fortifiers.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Article
  3. Balancing access to donor human milk: Rationing vs expanding use.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ting Ting FuPerinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0003-1522-7219
Heather C KaplanPerinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0003-0487-2781
Trayce FieldsTriHealth Good Samaritan Hospital, Cincinnati, OH 45220, USA.
Alonzo T FolgerDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Katelyn GordonDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Brenda B PoindexterPerinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein content is often inadequate in donor breast milk (DBM), resulting in poor growth. The use of protein-enriched target-pooled DBM (DBM+) has not been examined. We compared three cohorts of very low birth weight (VLBW) infants, born ≤ 1500 g: DBM cohort receiving > 1-week target-pooled DBM (20 kcal/oz), MBM cohort receiving ≤ 1-week DBM, and DBM+ cohort receiving > 1-week DBM+. Infants followed a standardized feeding regimen with additional fortification per clinical discretion. Growth velocities and z-scores were calculated for the first 4 weeks (

Indexed as

Bottle FeedingBreast Milk ExpressionChild DevelopmentFood, FortifiedMilk, HumanNutritive ValueAge FactorsBirth WeightBody HeightDietary ProteinsFemaleGestational AgeHumansInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightDietary Proteinsdonor breast milkgrowthhuman milkmilk analysispretermvery low birth weight

Identifiers

PMID34445027
PMCPMC8401419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.